Role of ros in aβ42 mediated cell surface p-selectin expression and actin polymerization

Research output: Contribution to journalArticle

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Abstract

P-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation. In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the development and progression of Alzhemer's disease. In this study we have evaluated the effects of Aβ42 oligomers on P-selectin expression and actin polymerization in mouse endothelial cells (bEnd3). Our results indicated that Aβ42 induced plasma membrane accumulation of P-selectin and promoted actin polymerization, and these events were correlated with increased reactive oxygen species (ROS) generation. The rapid, posttranslational cell signaling response mediated by ROS may well represent an important physiological trigger of the microvascular inflammation in Alzheimer disease.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalNeurology Asia
Volume19
Issue number3
Publication statusPublished - Sep 1 2014

Fingerprint

Selectins
P-Selectin
Polymerization
Actins
Reactive Oxygen Species
Inflammation
Actin Cytoskeleton
Blood Vessels
Disease Progression
Alzheimer Disease
Endothelial Cells
Cell Membrane

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Role of ros in aβ42 mediated cell surface p-selectin expression and actin polymerization. / Tsoy, Andrey; Shalakhmetova, Tamara; Umbayev, Bauyrzhan; Askarova, Sholpan.

In: Neurology Asia, Vol. 19, No. 3, 01.09.2014, p. 309-316.

Research output: Contribution to journalArticle

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