Role of yes-associated protein in cancer: An update (Review)

Ramazan Abylkassov, Yingqiu Xie

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Yes-associated protein (YAP) is an oncoprotein located in the cytoplasm in an inactive form, and when activated, it translocates to the nucleus and activates the transcription of genes responsible for cell division and apoptosis. YAP is one of the downstream regulatory proteins in the Hippo signaling pathway, which is important in cell proliferation and regeneration. Due to its great importance, YAP is regulated very strictly by different regulatory systems. The present review will focus on the canonical pathways of YAP, and will provide details on the most recent findings regarding its regulation and role in tumorigenesis, specifically in prostate tumor progression.

Original languageEnglish
Pages (from-to)2277-2282
Number of pages6
JournalOncology Letters
Volume12
Issue number4
DOIs
Publication statusPublished - Oct 1 2016

Keywords

  • Cancer
  • Prostate cancer
  • YAP

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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