Rotation of F1-ATPase

The stochastic model

Alexandra Pogrebnaya, Yury Romanovsky, Alexander Tikhonov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this work, we consider a stochastic model describing the unidirectional rotation of the rotor (subunit γ) of F1-ATPase. For appropriate choice of the model parameters, we used literature data on dynamic parameters of F1-ATPase and results of our calculations of electrostatic interactions in enzyme-substrate complex of the catalytic cycle. The model takes into account thermal fluctuations of the bath and stochastic processes of substrate binding and product dissociation from the catalytic centers. The model provides an adequate description of ATP-driven rotations of subunit in F 1-ATPase.

Original languageEnglish
JournalFluctuation and Noise Letters
Volume5
Issue number2
DOIs
Publication statusPublished - Jun 2005
Externally publishedYes

Fingerprint

ATP Synthase
Stochastic Model
Substrate
Electrostatics
Rotor
adenosine triphosphate
Stochastic Processes
stochastic processes
Enzymes
Model
Fluctuations
rotors
enzymes
Cycle
baths
dissociation
electrostatics
Interaction
cycles
products

Keywords

  • ATP hydrolysis
  • Electrostatic energy
  • F-ATPase
  • Molecular motor
  • Stochastic model of molecular motor

ASJC Scopus subject areas

  • Mathematics(all)

Cite this

Rotation of F1-ATPase : The stochastic model. / Pogrebnaya, Alexandra; Romanovsky, Yury; Tikhonov, Alexander.

In: Fluctuation and Noise Letters, Vol. 5, No. 2, 06.2005.

Research output: Contribution to journalArticle

Pogrebnaya, Alexandra ; Romanovsky, Yury ; Tikhonov, Alexander. / Rotation of F1-ATPase : The stochastic model. In: Fluctuation and Noise Letters. 2005 ; Vol. 5, No. 2.
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