Rotation of F1-ATPase: The stochastic model

Alexandra Pogrebnaya, Yury Romanovsky, Alexander Tikhonov

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4 Citations (Scopus)

Abstract

In this work, we consider a stochastic model describing the unidirectional rotation of the rotor (subunit γ) of F1-ATPase. For appropriate choice of the model parameters, we used literature data on dynamic parameters of F1-ATPase and results of our calculations of electrostatic interactions in enzyme-substrate complex of the catalytic cycle. The model takes into account thermal fluctuations of the bath and stochastic processes of substrate binding and product dissociation from the catalytic centers. The model provides an adequate description of ATP-driven rotations of subunit in F 1-ATPase.

Original languageEnglish
Pages (from-to)L217-L224
JournalFluctuation and Noise Letters
Volume5
Issue number2
DOIs
Publication statusPublished - Jun 1 2005
Externally publishedYes

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Keywords

  • ATP hydrolysis
  • Electrostatic energy
  • F-ATPase
  • Molecular motor
  • Stochastic model of molecular motor

ASJC Scopus subject areas

  • Mathematics(all)
  • Physics and Astronomy(all)

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