TY - JOUR
T1 - Rotation of F1-ATPase
T2 - The stochastic model
AU - Pogrebnaya, Alexandra
AU - Romanovsky, Yury
AU - Tikhonov, Alexander
N1 - Funding Information:
The authors are grateful to A. V. Voronov for useful and interesting discussions. This work was supported by grants from the Russian Foundation for Basic Researches (03-04-48981), INTAS (01-483 and 01-0450), the International Science and Technology Center (2296), Interdisciplinary projects from the Moscow State University, and grants for Russian Scientific Schools (1881.2003.4 and 2071.2003.4).
PY - 2005/6
Y1 - 2005/6
N2 - In this work, we consider a stochastic model describing the unidirectional rotation of the rotor (subunit γ) of F1-ATPase. For appropriate choice of the model parameters, we used literature data on dynamic parameters of F1-ATPase and results of our calculations of electrostatic interactions in enzyme-substrate complex of the catalytic cycle. The model takes into account thermal fluctuations of the bath and stochastic processes of substrate binding and product dissociation from the catalytic centers. The model provides an adequate description of ATP-driven rotations of subunit in F 1-ATPase.
AB - In this work, we consider a stochastic model describing the unidirectional rotation of the rotor (subunit γ) of F1-ATPase. For appropriate choice of the model parameters, we used literature data on dynamic parameters of F1-ATPase and results of our calculations of electrostatic interactions in enzyme-substrate complex of the catalytic cycle. The model takes into account thermal fluctuations of the bath and stochastic processes of substrate binding and product dissociation from the catalytic centers. The model provides an adequate description of ATP-driven rotations of subunit in F 1-ATPase.
KW - ATP hydrolysis
KW - Electrostatic energy
KW - F-ATPase
KW - Molecular motor
KW - Stochastic model of molecular motor
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U2 - 10.1142/S0219477505002586
DO - 10.1142/S0219477505002586
M3 - Article
AN - SCOPUS:23644436008
VL - 5
SP - L217-L224
JO - Fluctuation and Noise Letters
JF - Fluctuation and Noise Letters
SN - 0219-4775
IS - 2
ER -