SCORPION2: A database for structure-function analysis of scorpion toxins

Paul T.J. Tan, Anitha Veeramani, Kellathur N. Srinivasan, Shoba Ranganathan, Vladimir Brusic

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Scorpion toxins are important experimental tools for characterization of vast array of ion channels and serve as scaffolds for drug design. General public database entries contain limited annotation whereby rich structure-function information from mutation studies is typically not available. SCORPION2 contains more than 800 records of native and mutant toxin sequences enriched with binding affinity and toxicity information, 624 three-dimensional structures and some 500 references. SCORPION2 has a set of search and prediction tools that allow users to extract and perform specific queries: text searches of scorpion toxin records, sequence similarity search, extraction of sequences, visualization of scorpion toxin structures, analysis of toxic activity, and functional annotation of previously uncharacterized scorpion toxins. The SCORPION2 database is available at http://sdmc.i2r.a-star.edu.sg/scorpion/.

Original languageEnglish
Pages (from-to)356-363
Number of pages8
JournalToxicon
Volume47
Issue number3
DOIs
Publication statusPublished - Mar 1 2006

Keywords

  • Database
  • Mutation
  • Scorpion toxin
  • Structure-function relationship

ASJC Scopus subject areas

  • Toxicology

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