Serial study of liver-directed autoantibodies and autoreactive T-lymphocytes in acute viral hepatitis B

Sandro Vento, Barbara M. McFarlane, Tiziana Garofano Vento, Sergio Ranieri, Elio G. Rondanelli, Ian G. McFarlane, Roger Williams, Adrian L W F Eddleston

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

To explore the mechanisms underlying liver-directed autoimmune reactions in acute Hepatitis B Virus (HBV) infection, we followed five subjects who were identified in the early incubation phase (30-70 days before the first elevation of transaminases). We assessed serially cellular (using a T-lymphocyte migration inhibitory factor assay) and humoral (RIA) immunity to LSP (a macromolecular, liver-derived lipoprotein complex) and hepatic lectin (HL), the liver-specific receptor for desialylated glycoproteins, which appears to be a major target antigen for autoreactions in autoimmune chronic active hepatitis. Anti-LSP and anti-HL autoantibodies were found, at some stage during acute HBV infection, in 4 5 subjects, whereas cellular immunity to the same antigens was detected in only two patients. Sustained production of anti-HL antibodies was noted only in patients showing cellular immunity to this antigen and was apparently secondary to liver damage, whereas anti-LSP antibodies were first detected at the onset of liver injury when there was no evidence of T-cell immunity to the same antigenic complex. One explanation for this apparent dichotomy between cellular and humoral responses to LSP is that a helper T-cell response to the major envelope component of HBV, HBsAg, which precedes by 10-20 days the development of anti-LSP antibodies, promotes a humoral reaction to autoantigens contained in the LSP preparation, coexpressed with HBsAg, on the surface of infected hepatocytes.

Original languageEnglish
Pages (from-to)299-307
Number of pages9
JournalJournal of Autoimmunity
Volume1
Issue number3
DOIs
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Hepatitis B
Autoantibodies
Asialoglycoprotein Receptor
T-Lymphocytes
Hepatitis B virus
Liver
Virus Diseases
Hepatitis B Surface Antigens
Antigens
Cellular Immunity
Anti-Idiotypic Antibodies
Asialoglycoproteins
Autoimmune Hepatitis
Chronic Hepatitis
Humoral Immunity
Helper-Inducer T-Lymphocytes
Transaminases
Lipoproteins
Hepatocytes
Immunity

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Vento, S., McFarlane, B. M., Vento, T. G., Ranieri, S., Rondanelli, E. G., McFarlane, I. G., ... Eddleston, A. L. W. F. (1988). Serial study of liver-directed autoantibodies and autoreactive T-lymphocytes in acute viral hepatitis B. Journal of Autoimmunity, 1(3), 299-307. https://doi.org/10.1016/0896-8411(88)90034-0

Serial study of liver-directed autoantibodies and autoreactive T-lymphocytes in acute viral hepatitis B. / Vento, Sandro; McFarlane, Barbara M.; Vento, Tiziana Garofano; Ranieri, Sergio; Rondanelli, Elio G.; McFarlane, Ian G.; Williams, Roger; Eddleston, Adrian L W F.

In: Journal of Autoimmunity, Vol. 1, No. 3, 1988, p. 299-307.

Research output: Contribution to journalArticle

Vento, S, McFarlane, BM, Vento, TG, Ranieri, S, Rondanelli, EG, McFarlane, IG, Williams, R & Eddleston, ALWF 1988, 'Serial study of liver-directed autoantibodies and autoreactive T-lymphocytes in acute viral hepatitis B', Journal of Autoimmunity, vol. 1, no. 3, pp. 299-307. https://doi.org/10.1016/0896-8411(88)90034-0
Vento, Sandro ; McFarlane, Barbara M. ; Vento, Tiziana Garofano ; Ranieri, Sergio ; Rondanelli, Elio G. ; McFarlane, Ian G. ; Williams, Roger ; Eddleston, Adrian L W F. / Serial study of liver-directed autoantibodies and autoreactive T-lymphocytes in acute viral hepatitis B. In: Journal of Autoimmunity. 1988 ; Vol. 1, No. 3. pp. 299-307.
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