Serum prostate-specific antigen levels in Middle Eastern men with subclinical prostatitis

J. T. Anim, E. O. Kehinde, M. A. Sheikh, A. Prasad, O. A. Mojiminiyi, Y. Ali, K. A. Al-Awadi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Objective: To investigate the influence of subclinical or histologically diagnosed prostatitis on serum prostate-specific antigen (PSA) in patients investigated for prostatic disease in Kuwait. Materials and Methods: Serum PSA was assayed in patients investigated for prostatic disease in Mubarak Al-Kabeer Hospital, Kuwait, between December 2002 and December 2004. These included patients undergoing transrectal ultrasound with needle biopsy of the prostate gland and those who were treated with transurethral resection of the prostate or retropubic prostatectomy. The tissue was evaluated for prostatitis as well as the underlying disease, and the type and severity of prostatitis were compared with levels of serum PSA. Results: Of the 331 tissue specimens, 18 (5.4%) did not show prostatitis, while 233 (70.4%) with benign prostate and 80 (24.2%) with malignant prostate disease showed prostatitis. Of 270 men with known serum PSA levels, 198 and 72 had benign and malignant prostate disease, respectively. Of the 198, 77 (41%) with benign prostate disease and prostatitis and of the 72, 52 (76%) with malignant prostate disease and prostatitis had serum PSA levels >10 ng/ml. Conclusion: The data showed that although raised serum PSA is more commonly associated with prostate cancer, subclinical prostatitis is a significant source of high serum PSA in over 40% of men in Kuwait. That local factors may obscure the usefulness of serum PSA as a screening tool suggests the need for a locally applicable paradigm to identify prostate cancer.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalMedical Principles and Practice
Issue number1
Publication statusPublished - Dec 2006


  • Benign prostate disease
  • Middle Eastern men
  • Prostate cancer
  • Prostate-specific antigen
  • Prostatitis

ASJC Scopus subject areas

  • Medicine(all)

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