Severe somatoform and dysautonomic syndromes after HPV vaccination

Case series and review of literature

Beniamino Palmieri, Dimitri Poddighe, Maria Vadalà, Carmen Laurino, Carla Carnovale, Emilio Clementi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil® and Cervarix®. Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection of symptoms, indicating nervous system dysfunction, has been described after HPV vaccination. We retrospectively described a case series including 18 girls (aged 12-24 years) referred to our ‘‘Second Opinion Medical Network’’ for the evaluation of ‘‘neuropathy with autonomic dysfunction’’ after HPV vaccination. All girls complained of long-lasting and invalidating somatoform symptoms (including asthenia, headache, cognitive dysfunctions, myalgia, sinus tachycardia and skin rashes) that have developed 1-5 days (n = 11), 5-15 days (n = 5) and 15-20 days (n = 2) after the vaccination. These cases can be included in the recently described immune dysfunction named autoimmune/inflammatory syndrome induced by adjuvants (ASIA). HPV vaccine, through its adjuvant component, is speculated to induce an abnormal activation of the immune system, involving glia cells in the nervous system too. Further researches should aim at defining the pathological and clinical aspects of these post-vaccination diseases and identifying a genetic background predisposing to these adverse reactions.

Original languageEnglish
Pages (from-to)106-116
Number of pages11
JournalImmunologic Research
Volume65
Issue number1
DOIs
Publication statusPublished - Feb 1 2017
Externally publishedYes

Fingerprint

Papillomaviridae
Vaccination
Papillomavirus Vaccines
Nervous System
Sinus Tachycardia
Asthenia
Myalgia
Viral Proteins
Exanthema
Neuroglia
Uterine Cervical Neoplasms
Headache
Immune System
Referral and Consultation
Vaccines
Research

Keywords

  • Adjuvant
  • ADR
  • ASIA
  • Autoimmune syndrome
  • HPV
  • Symptoms
  • Vaccine

ASJC Scopus subject areas

  • Immunology

Cite this

Severe somatoform and dysautonomic syndromes after HPV vaccination : Case series and review of literature. / Palmieri, Beniamino; Poddighe, Dimitri; Vadalà, Maria; Laurino, Carmen; Carnovale, Carla; Clementi, Emilio.

In: Immunologic Research, Vol. 65, No. 1, 01.02.2017, p. 106-116.

Research output: Contribution to journalArticle

Palmieri, Beniamino ; Poddighe, Dimitri ; Vadalà, Maria ; Laurino, Carmen ; Carnovale, Carla ; Clementi, Emilio. / Severe somatoform and dysautonomic syndromes after HPV vaccination : Case series and review of literature. In: Immunologic Research. 2017 ; Vol. 65, No. 1. pp. 106-116.
@article{d25f6f6a6b9948bc8de0510d2f6fbeeb,
title = "Severe somatoform and dysautonomic syndromes after HPV vaccination: Case series and review of literature",
abstract = "Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil{\circledR} and Cervarix{\circledR}. Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection of symptoms, indicating nervous system dysfunction, has been described after HPV vaccination. We retrospectively described a case series including 18 girls (aged 12-24 years) referred to our ‘‘Second Opinion Medical Network’’ for the evaluation of ‘‘neuropathy with autonomic dysfunction’’ after HPV vaccination. All girls complained of long-lasting and invalidating somatoform symptoms (including asthenia, headache, cognitive dysfunctions, myalgia, sinus tachycardia and skin rashes) that have developed 1-5 days (n = 11), 5-15 days (n = 5) and 15-20 days (n = 2) after the vaccination. These cases can be included in the recently described immune dysfunction named autoimmune/inflammatory syndrome induced by adjuvants (ASIA). HPV vaccine, through its adjuvant component, is speculated to induce an abnormal activation of the immune system, involving glia cells in the nervous system too. Further researches should aim at defining the pathological and clinical aspects of these post-vaccination diseases and identifying a genetic background predisposing to these adverse reactions.",
keywords = "Adjuvant, ADR, ASIA, Autoimmune syndrome, HPV, Symptoms, Vaccine",
author = "Beniamino Palmieri and Dimitri Poddighe and Maria Vadal{\`a} and Carmen Laurino and Carla Carnovale and Emilio Clementi",
year = "2017",
month = "2",
day = "1",
doi = "10.1007/s12026-016-8820-z",
language = "English",
volume = "65",
pages = "106--116",
journal = "Immunologic Research",
issn = "0257-277X",
publisher = "Humana Press",
number = "1",

}

TY - JOUR

T1 - Severe somatoform and dysautonomic syndromes after HPV vaccination

T2 - Case series and review of literature

AU - Palmieri, Beniamino

AU - Poddighe, Dimitri

AU - Vadalà, Maria

AU - Laurino, Carmen

AU - Carnovale, Carla

AU - Clementi, Emilio

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil® and Cervarix®. Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection of symptoms, indicating nervous system dysfunction, has been described after HPV vaccination. We retrospectively described a case series including 18 girls (aged 12-24 years) referred to our ‘‘Second Opinion Medical Network’’ for the evaluation of ‘‘neuropathy with autonomic dysfunction’’ after HPV vaccination. All girls complained of long-lasting and invalidating somatoform symptoms (including asthenia, headache, cognitive dysfunctions, myalgia, sinus tachycardia and skin rashes) that have developed 1-5 days (n = 11), 5-15 days (n = 5) and 15-20 days (n = 2) after the vaccination. These cases can be included in the recently described immune dysfunction named autoimmune/inflammatory syndrome induced by adjuvants (ASIA). HPV vaccine, through its adjuvant component, is speculated to induce an abnormal activation of the immune system, involving glia cells in the nervous system too. Further researches should aim at defining the pathological and clinical aspects of these post-vaccination diseases and identifying a genetic background predisposing to these adverse reactions.

AB - Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil® and Cervarix®. Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection of symptoms, indicating nervous system dysfunction, has been described after HPV vaccination. We retrospectively described a case series including 18 girls (aged 12-24 years) referred to our ‘‘Second Opinion Medical Network’’ for the evaluation of ‘‘neuropathy with autonomic dysfunction’’ after HPV vaccination. All girls complained of long-lasting and invalidating somatoform symptoms (including asthenia, headache, cognitive dysfunctions, myalgia, sinus tachycardia and skin rashes) that have developed 1-5 days (n = 11), 5-15 days (n = 5) and 15-20 days (n = 2) after the vaccination. These cases can be included in the recently described immune dysfunction named autoimmune/inflammatory syndrome induced by adjuvants (ASIA). HPV vaccine, through its adjuvant component, is speculated to induce an abnormal activation of the immune system, involving glia cells in the nervous system too. Further researches should aim at defining the pathological and clinical aspects of these post-vaccination diseases and identifying a genetic background predisposing to these adverse reactions.

KW - Adjuvant

KW - ADR

KW - ASIA

KW - Autoimmune syndrome

KW - HPV

KW - Symptoms

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=85021968708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021968708&partnerID=8YFLogxK

U2 - 10.1007/s12026-016-8820-z

DO - 10.1007/s12026-016-8820-z

M3 - Article

VL - 65

SP - 106

EP - 116

JO - Immunologic Research

JF - Immunologic Research

SN - 0257-277X

IS - 1

ER -