Simple guidelines for a self-built laboratory-scale supercritical anti-solvent system

G. H. Chong, R. Yunus, T. S Y Choong, N. Abdullah, S. Y. Spotar

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A technique to generate supercritical fluid (SCF) particles has gained attention in pharmaceutical, cosmetic and paint applications. However, the scarcity of information on the design of this type of laboratory-scale equipment is a significant obstacle to its technological progress. Therefore, the purpose of this study was to design and develop a laboratory supercritical anti-solvent (SAS) system for producing microparticles and microcapsules of acetaminophen. The designed SAS system was operated at 110 bars of pressure, 35 °C, 35 mg/ml polymer concentration and 1.75 ml/min feed flow rate. The morphological, thermal and crystallographic properties of the microparticles and microcapsules were characterised using scanning electron microscopy, thermogravimetric analysis and X-ray powder diffraction, respectively. The in vitro drug release by the microparticles and microcapsules was also investigated. Following the SAS process, a more homogenous microparticle size distribution was observed in addition to a change in the crystallinity, and the drug thermal stability was maintained. Furthermore, the microcapsules significantly prolonged the drug release during the in vitro study. These results demonstrate that the designed SAS system successfully produced microparticles and microcapsules of the selected drug.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalJournal of Supercritical Fluids
Volume60
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

Fingerprint

microparticles
Capsules
drugs
Pharmaceutical Preparations
Supercritical fluids
Cosmetics
Paint
X ray powder diffraction
Drug products
supercritical fluids
Thermogravimetric analysis
paints
Acetaminophen
Thermodynamic stability
Flow rate
crystallinity
Polymers
thermal stability
flow velocity
thermodynamic properties

Keywords

  • Encapsulation
  • Microcapsule
  • Particle formation
  • SAS design
  • Supercritical fluids

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Chemical Engineering(all)
  • Condensed Matter Physics

Cite this

Simple guidelines for a self-built laboratory-scale supercritical anti-solvent system. / Chong, G. H.; Yunus, R.; Choong, T. S Y; Abdullah, N.; Spotar, S. Y.

In: Journal of Supercritical Fluids, Vol. 60, 12.2011, p. 69-74.

Research output: Contribution to journalArticle

Chong, G. H. ; Yunus, R. ; Choong, T. S Y ; Abdullah, N. ; Spotar, S. Y. / Simple guidelines for a self-built laboratory-scale supercritical anti-solvent system. In: Journal of Supercritical Fluids. 2011 ; Vol. 60. pp. 69-74.
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