Abstract
A technique to generate supercritical fluid (SCF) particles has gained attention in pharmaceutical, cosmetic and paint applications. However, the scarcity of information on the design of this type of laboratory-scale equipment is a significant obstacle to its technological progress. Therefore, the purpose of this study was to design and develop a laboratory supercritical anti-solvent (SAS) system for producing microparticles and microcapsules of acetaminophen. The designed SAS system was operated at 110 bars of pressure, 35 °C, 35 mg/ml polymer concentration and 1.75 ml/min feed flow rate. The morphological, thermal and crystallographic properties of the microparticles and microcapsules were characterised using scanning electron microscopy, thermogravimetric analysis and X-ray powder diffraction, respectively. The in vitro drug release by the microparticles and microcapsules was also investigated. Following the SAS process, a more homogenous microparticle size distribution was observed in addition to a change in the crystallinity, and the drug thermal stability was maintained. Furthermore, the microcapsules significantly prolonged the drug release during the in vitro study. These results demonstrate that the designed SAS system successfully produced microparticles and microcapsules of the selected drug.
| Original language | English |
|---|---|
| Pages (from-to) | 69-74 |
| Number of pages | 6 |
| Journal | Journal of Supercritical Fluids |
| Volume | 60 |
| DOIs | |
| Publication status | Published - Dec 2011 |
| Externally published | Yes |
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Keywords
- Encapsulation
- Microcapsule
- Particle formation
- SAS design
- Supercritical fluids
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Chemical Engineering(all)
- Condensed Matter Physics
Cite this
Simple guidelines for a self-built laboratory-scale supercritical anti-solvent system. / Chong, G. H.; Yunus, R.; Choong, T. S Y; Abdullah, N.; Spotar, S. Y.
In: Journal of Supercritical Fluids, Vol. 60, 12.2011, p. 69-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simple guidelines for a self-built laboratory-scale supercritical anti-solvent system
AU - Chong, G. H.
AU - Yunus, R.
AU - Choong, T. S Y
AU - Abdullah, N.
AU - Spotar, S. Y.
PY - 2011/12
Y1 - 2011/12
N2 - A technique to generate supercritical fluid (SCF) particles has gained attention in pharmaceutical, cosmetic and paint applications. However, the scarcity of information on the design of this type of laboratory-scale equipment is a significant obstacle to its technological progress. Therefore, the purpose of this study was to design and develop a laboratory supercritical anti-solvent (SAS) system for producing microparticles and microcapsules of acetaminophen. The designed SAS system was operated at 110 bars of pressure, 35 °C, 35 mg/ml polymer concentration and 1.75 ml/min feed flow rate. The morphological, thermal and crystallographic properties of the microparticles and microcapsules were characterised using scanning electron microscopy, thermogravimetric analysis and X-ray powder diffraction, respectively. The in vitro drug release by the microparticles and microcapsules was also investigated. Following the SAS process, a more homogenous microparticle size distribution was observed in addition to a change in the crystallinity, and the drug thermal stability was maintained. Furthermore, the microcapsules significantly prolonged the drug release during the in vitro study. These results demonstrate that the designed SAS system successfully produced microparticles and microcapsules of the selected drug.
AB - A technique to generate supercritical fluid (SCF) particles has gained attention in pharmaceutical, cosmetic and paint applications. However, the scarcity of information on the design of this type of laboratory-scale equipment is a significant obstacle to its technological progress. Therefore, the purpose of this study was to design and develop a laboratory supercritical anti-solvent (SAS) system for producing microparticles and microcapsules of acetaminophen. The designed SAS system was operated at 110 bars of pressure, 35 °C, 35 mg/ml polymer concentration and 1.75 ml/min feed flow rate. The morphological, thermal and crystallographic properties of the microparticles and microcapsules were characterised using scanning electron microscopy, thermogravimetric analysis and X-ray powder diffraction, respectively. The in vitro drug release by the microparticles and microcapsules was also investigated. Following the SAS process, a more homogenous microparticle size distribution was observed in addition to a change in the crystallinity, and the drug thermal stability was maintained. Furthermore, the microcapsules significantly prolonged the drug release during the in vitro study. These results demonstrate that the designed SAS system successfully produced microparticles and microcapsules of the selected drug.
KW - Encapsulation
KW - Microcapsule
KW - Particle formation
KW - SAS design
KW - Supercritical fluids
UR - http://www.scopus.com/inward/record.url?scp=81355149894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81355149894&partnerID=8YFLogxK
U2 - 10.1016/j.supflu.2011.04.020
DO - 10.1016/j.supflu.2011.04.020
M3 - Article
VL - 60
SP - 69
EP - 74
JO - Journal of Supercritical Fluids
JF - Journal of Supercritical Fluids
SN - 0896-8446
ER -