Skene's gland tumor - A curious histological appearance and a prolonged clinical outcome: A case report

A 64-year-old woman was admitted for complaints in the lower urinary tract. A large, widely pedunculated tumor was observed, arising close to the external urethral orifice. Urethrocystoscopy revealed urethral papillary protrusions in the region of the internal orifice and bladder neck. The histopathological examination presented well-differentiated papillary adenocarcinoma, neither of intestinal tract nor of urinary bladder origin. Although immunohistochemistry for prostate-specific antigen was negative, a diagnosis of Skene's gland adenocarcinoma was established. After the external tumor had been removed, and urethral papillary formations electroresected, the patient's symptoms significantly decreased. Half a year later, a recurrence of the same histology-type papillary tumor in the region of internal urethral orifice was diagnosed. The patient refused to undergo radical surgery. During the next five years, the patient underwent a regular quarterly-semiannual transurethral electroresection of the tumor, and is in good condition.