TY - JOUR
T1 - Sleep, brain vascular health and ageing
AU - Mahalakshmi, Arehally M.
AU - Ray, Bipul
AU - Tuladhar, Sunanda
AU - Bhat, Abid
AU - Bishir, Muhammed
AU - Bolla, Srinivasa Rao
AU - Yang, Jian
AU - Essa, Musthafa Mohamed
AU - Chidambaram, Saravana Babu
AU - Guillemin, Gilles J.
AU - Sakharkar, Meena Kishore
N1 - Funding Information:
AMM is thankful to JSS AHER, Mysuru, for providing the seed grant. GJG is supported by the NMHRC, the ARC and Macquarie University.
Publisher Copyright:
© 2020, American Aging Association.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Sleep maintains the function of the entire body through homeostasis. Chronic sleep deprivation (CSD) is a prime health concern in the modern world. Previous reports have shown that CSD has profound negative effects on brain vasculature at both the cellular and molecular levels, and that this is a major cause of cognitive dysfunction and early vascular ageing. However, correlations among sleep deprivation (SD), brain vascular changes and ageing have barely been looked into. This review attempts to correlate the alterations in the levels of major neurotransmitters (acetylcholine, adrenaline, GABA and glutamate) and signalling molecules (Sirt1, PGC1α, FOXO, P66shc, PARP1) in SD and changes in brain vasculature, cognitive dysfunction and early ageing. It also aims to connect SD-induced loss in the number of dendritic spines and their effects on alterations in synaptic plasticity, cognitive disabilities and early vascular ageing based on data available in scientific literature. To the best of our knowledge, this is the first article providing a pathophysiological basis to link SD to brain vascular ageing.
AB - Sleep maintains the function of the entire body through homeostasis. Chronic sleep deprivation (CSD) is a prime health concern in the modern world. Previous reports have shown that CSD has profound negative effects on brain vasculature at both the cellular and molecular levels, and that this is a major cause of cognitive dysfunction and early vascular ageing. However, correlations among sleep deprivation (SD), brain vascular changes and ageing have barely been looked into. This review attempts to correlate the alterations in the levels of major neurotransmitters (acetylcholine, adrenaline, GABA and glutamate) and signalling molecules (Sirt1, PGC1α, FOXO, P66shc, PARP1) in SD and changes in brain vasculature, cognitive dysfunction and early ageing. It also aims to connect SD-induced loss in the number of dendritic spines and their effects on alterations in synaptic plasticity, cognitive disabilities and early vascular ageing based on data available in scientific literature. To the best of our knowledge, this is the first article providing a pathophysiological basis to link SD to brain vascular ageing.
KW - Cognition
KW - Neurochemicals
KW - Sleep deprivation
KW - Synaptic plasticity
KW - Vascular ageing
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U2 - 10.1007/s11357-020-00235-8
DO - 10.1007/s11357-020-00235-8
M3 - Review article
C2 - 32748314
AN - SCOPUS:85088940496
SN - 2509-2715
VL - 42
SP - 1257
EP - 1283
JO - GeroScience
JF - GeroScience
IS - 5
ER -