Somatoform and neurocognitive syndromes after HPV immunization are not associated to cell-mediated hypersensitivity to aluminum

Dimitri Poddighe, Maria Vadalà, Carmen Laurino, Beniaminoi Palmieri

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Vaccines against human papilloma virus (HPV) have been demonstrated to be very effective to prevent infection-related neoplasms. However, several reports describing heterogeneous post-vaccination phenomena have been published in last few years. The spectrum of these disorders includes both immune-mediated neurological diseases and neuropsychiatric functional disorders. Some researchers speculated about a genetic predisposition, but others hypothesized a role of adjuvants, including some metals and, particularly, aluminum. Here, we tested sixteen young girls developing somatoform and neurocognitive syndromes after the HPV immunization, through MELISA® test, detecting cell-mediated hypersensitivity to several metals. We found no association between these neurocognitive disorders and the results provided by this test; importantly, no patients showed hypersensitivity to aluminum, which is the inorganic adjuvant included in HPV vaccines. Thus, if aluminum played a role in the pathophysiology of musculoskeletal and neurocognitive disturbances occurring in some young girls after HPV immunization, that should recognize other mechanisms than the activation of aluminum-specific lymphocytes.

Original languageEnglish
Pages (from-to)58-61
Number of pages4
JournalToxicology in Vitro
Volume43
DOIs
Publication statusPublished - Sep 1 2017
Externally publishedYes

Keywords

  • Aluminum
  • HPV
  • MELISA test
  • Neuro-cognitive syndromes
  • Post-vaccination phenomena
  • Vaccine

ASJC Scopus subject areas

  • Toxicology

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