Stimuliatsiia postradiatsionnoǐ regeneratsii éritropoeza u mysheǐ pod deǐstviem vaktsiny Bordetella pertussis.

Translated title of the contribution: Stimulation of postradiation regeneration of erythropoiesis in mice with Bordetells pertussis vaccine

V. V. Khorobrykh, A. V. Sanin, N. S. Barteneva, A. E. Snegireva

Research output: Contribution to journalArticle

Abstract

Inoculation into mice of killed B. pertussis vaccine (10(10) microbial cells) one day before their sublethal irradiation (6.0 Gy) was accompanied by accelerated regeneration of erythropoiesis in the bone marrow, particularly in the spleen as was judged by the 59Fe incorporation. B. pertussis also induced an increase in endocolonization when inoculated 4-5 days after irradiation. The latter suggests a possible effect of vaccine on the hematopoietic cells, less differentiated than erythropoietin-sensitive cells (ESC), inasmuch the sensitivity of the ESC to erythropoietin commonly appeared at the later stages. When B. pertussis was inoculated into BALB/c mice one day before their infection by Rauscher's leukemia virus noticeable activation of leukemogenicity was observed. It is believed that the reason for this is the stimulation of erythroid target cells for the virus after B. pertussis vaccination. The data obtained indicate that B. pertussis vaccine activates erythropoiesis in both normal and irradiated mice.

Original languageRussian
Pages (from-to)94-97
Number of pages4
JournalByulleten Eksperimentalnoi Biologii i Meditsiny
Volume96
Issue number8
Publication statusPublished - Aug 1983
Externally publishedYes

Fingerprint

Pertussis Vaccine
Erythropoiesis
Erythropoietin
Whooping Cough
Regeneration
Viruses
Irradiation
Rauscher Virus
Cercopithecine Herpesvirus 1
Virus Activation
Erythroid Cells
Bone
Vaccines
Chemical activation
Vaccination
Spleen
Bone Marrow
Infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Stimuliatsiia postradiatsionnoǐ regeneratsii éritropoeza u mysheǐ pod deǐstviem vaktsiny Bordetella pertussis. / Khorobrykh, V. V.; Sanin, A. V.; Barteneva, N. S.; Snegireva, A. E.

In: Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 96, No. 8, 08.1983, p. 94-97.

Research output: Contribution to journalArticle

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