Stimuli-sensitive polymeric system for biomedical imaging

Cheol Hee Ahn, Chang Keun Lim, Jin Seong Lee, Soo Young Park

Research output: Contribution to conferencePaperpeer-review

Abstract

We demonstrate a novel stimuli-sensitive sensor working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In the design of molecular probe, labile groups cleavable under acidic condition were introduced as a model recognition site to explore the possible application of this system to the sensors detecting the presence of specific enzymes. Aiming at the biochip-based array detection, our fluorescent probe (Si-Py-Ac-PEG) was designed to comprise PEGylated pyrene with acid cleavable acetal spacer and to be tethered to the glass substrate.

Original languageEnglish
Pages5249-5250
Number of pages2
Publication statusPublished - Dec 1 2006
Externally publishedYes
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006

Conference

Conference55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/069/22/06

Keywords

  • Aggregation induced enhanced aggregation (AIEE)
  • Fluorescence resonance energy transfer (FRET)
  • Molecular imaging
  • Stimuli-sensitive

ASJC Scopus subject areas

  • Engineering(all)

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