Abstract
We demonstrate a novel stimuli-sensitive sensor working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In the design of molecular probe, labile groups cleavable under acidic condition were introduced as a model recognition site to explore the possible application of this system to the sensors detecting the presence of specific enzymes. Aiming at the biochip-based array detection, our fluorescent probe (Si-Py-Ac-PEG) was designed to comprise PEGylated pyrene with acid cleavable acetal spacer and to be tethered to the glass substrate.
Original language | English |
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Pages | 5249-5250 |
Number of pages | 2 |
Publication status | Published - Dec 1 2006 |
Externally published | Yes |
Event | 55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: Sep 20 2006 → Sep 22 2006 |
Conference
Conference | 55th Society of Polymer Science Japan Symposium on Macromolecules |
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Country | Japan |
City | Toyama |
Period | 9/20/06 → 9/22/06 |
Keywords
- Aggregation induced enhanced aggregation (AIEE)
- Fluorescence resonance energy transfer (FRET)
- Molecular imaging
- Stimuli-sensitive
ASJC Scopus subject areas
- Engineering(all)