Stimuli-sensitive polymeric system for biomedical imaging

Cheol Hee Ahn; Chang Keun Lim; Jin Seong Lee; Soo Young Park

Stimuli-sensitive polymeric system for biomedical imaging

Cheol Hee Ahn, Chang Keun Lim, Jin Seong Lee, Soo Young Park

Research output: Contribution to conference › Paper › peer-review

Abstract

We demonstrate a novel stimuli-sensitive sensor working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In the design of molecular probe, labile groups cleavable under acidic condition were introduced as a model recognition site to explore the possible application of this system to the sensors detecting the presence of specific enzymes. Aiming at the biochip-based array detection, our fluorescent probe (Si-Py-Ac-PEG) was designed to comprise PEGylated pyrene with acid cleavable acetal spacer and to be tethered to the glass substrate.

Original language	English
Pages	5249-5250
Number of pages	2
Publication status	Published - Dec 1 2006
Externally published	Yes
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: Sep 20 2006 → Sep 22 2006

Conference

Conference	55th Society of Polymer Science Japan Symposium on Macromolecules
Country	Japan
City	Toyama
Period	9/20/06 → 9/22/06

Keywords

Aggregation induced enhanced aggregation (AIEE)
Fluorescence resonance energy transfer (FRET)
Molecular imaging
Stimuli-sensitive

ASJC Scopus subject areas

Engineering(all)

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Cite this

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title = "Stimuli-sensitive polymeric system for biomedical imaging",

abstract = "We demonstrate a novel stimuli-sensitive sensor working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In the design of molecular probe, labile groups cleavable under acidic condition were introduced as a model recognition site to explore the possible application of this system to the sensors detecting the presence of specific enzymes. Aiming at the biochip-based array detection, our fluorescent probe (Si-Py-Ac-PEG) was designed to comprise PEGylated pyrene with acid cleavable acetal spacer and to be tethered to the glass substrate.",

keywords = "Aggregation induced enhanced aggregation (AIEE), Fluorescence resonance energy transfer (FRET), Molecular imaging, Stimuli-sensitive",

author = "Ahn, {Cheol Hee} and Lim, {Chang Keun} and Lee, {Jin Seong} and Park, {Soo Young}",

year = "2006",

month = dec,

day = "1",

language = "English",

pages = "5249--5250",

note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

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TY - CONF

T1 - Stimuli-sensitive polymeric system for biomedical imaging

AU - Ahn, Cheol Hee

AU - Lim, Chang Keun

AU - Lee, Jin Seong

AU - Park, Soo Young

PY - 2006/12/1

Y1 - 2006/12/1

N2 - We demonstrate a novel stimuli-sensitive sensor working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In the design of molecular probe, labile groups cleavable under acidic condition were introduced as a model recognition site to explore the possible application of this system to the sensors detecting the presence of specific enzymes. Aiming at the biochip-based array detection, our fluorescent probe (Si-Py-Ac-PEG) was designed to comprise PEGylated pyrene with acid cleavable acetal spacer and to be tethered to the glass substrate.

AB - We demonstrate a novel stimuli-sensitive sensor working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In the design of molecular probe, labile groups cleavable under acidic condition were introduced as a model recognition site to explore the possible application of this system to the sensors detecting the presence of specific enzymes. Aiming at the biochip-based array detection, our fluorescent probe (Si-Py-Ac-PEG) was designed to comprise PEGylated pyrene with acid cleavable acetal spacer and to be tethered to the glass substrate.

KW - Aggregation induced enhanced aggregation (AIEE)

KW - Fluorescence resonance energy transfer (FRET)

KW - Molecular imaging

KW - Stimuli-sensitive

UR - http://www.scopus.com/inward/record.url?scp=33846175420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846175420&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33846175420

SP - 5249

EP - 5250

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -