Structural characteristics of activated carbons and ibuprofen adsorption affected by bovine serum albumin

M. Melillo, V. M. Gun'ko, S. R. Tennison, L. I. Mikhalovska, G. J. Phillips, J. G. Davies, A. W. Lloyd, O. P. Kozynchenko, D. J. Malik, M. Streat, S. V. Mikhalovsky

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Structural characteristics of a series of MAST carbons were studied using scanning electron microscopy images and the nitrogen adsorption isotherms analyzed with several models of pores and different adsorption equations. A developed model of pores as a mixture of gaps between spherical nanoparticles and slitlike pores was found appropriate for MAST carbons. Adsorption of ibuprofen [2-(4-isobutylphenyl)propionic acid] on activated carbons possessing different pore size distributions in protein-free and bovine serum albumin (BSA)-containing aqueous solutions reveals the importance of the contribution of mesopores to the total porosity of adsorbents. The influence of the mesoporosity increases when considering the removal of the drug from the protein-containing solution. Cellulose-coated microporous carbon Norit RBX adsorbs significantly smaller amounts of ibuprofen than uncoated micro/mesoporous MAST carbons whose adsorption capability increases with increasing mesoporosity and specific surface area, burnoff dependent variable. A similar effect of broad pores is observed on adsorption of fibrinogen on the same carbons. Analysis of the ibuprofen adsorption data using Langmuir and D'Arcy-Watt equations as the kernel of the Fredbolm integral equation shows that the nonuniformity of ibuprofen adsorption complexes diminishes with the presence of BSA. This effect may be explained by a partial adsorption of ibuprofen onto protein molecules immobilized on carbon particles and blocking of a portion of narrow pores.

Original languageEnglish
Pages (from-to)2837-2851
Number of pages15
JournalLangmuir
Volume20
Issue number7
DOIs
Publication statusPublished - Mar 30 2004
Externally publishedYes

Fingerprint

Ibuprofen
activated carbon
Bovine Serum Albumin
albumins
serums
Activated carbon
Carbon
Adsorption
adsorption
porosity
carbon
Proteins
proteins
Propionic acid
Charcoal
fibrinogen
propionic acid
dependent variables
Adsorption isotherms
Cellulose

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Melillo, M., Gun'ko, V. M., Tennison, S. R., Mikhalovska, L. I., Phillips, G. J., Davies, J. G., ... Mikhalovsky, S. V. (2004). Structural characteristics of activated carbons and ibuprofen adsorption affected by bovine serum albumin. Langmuir, 20(7), 2837-2851. https://doi.org/10.1021/la0360557

Structural characteristics of activated carbons and ibuprofen adsorption affected by bovine serum albumin. / Melillo, M.; Gun'ko, V. M.; Tennison, S. R.; Mikhalovska, L. I.; Phillips, G. J.; Davies, J. G.; Lloyd, A. W.; Kozynchenko, O. P.; Malik, D. J.; Streat, M.; Mikhalovsky, S. V.

In: Langmuir, Vol. 20, No. 7, 30.03.2004, p. 2837-2851.

Research output: Contribution to journalArticle

Melillo, M, Gun'ko, VM, Tennison, SR, Mikhalovska, LI, Phillips, GJ, Davies, JG, Lloyd, AW, Kozynchenko, OP, Malik, DJ, Streat, M & Mikhalovsky, SV 2004, 'Structural characteristics of activated carbons and ibuprofen adsorption affected by bovine serum albumin', Langmuir, vol. 20, no. 7, pp. 2837-2851. https://doi.org/10.1021/la0360557
Melillo M, Gun'ko VM, Tennison SR, Mikhalovska LI, Phillips GJ, Davies JG et al. Structural characteristics of activated carbons and ibuprofen adsorption affected by bovine serum albumin. Langmuir. 2004 Mar 30;20(7):2837-2851. https://doi.org/10.1021/la0360557
Melillo, M. ; Gun'ko, V. M. ; Tennison, S. R. ; Mikhalovska, L. I. ; Phillips, G. J. ; Davies, J. G. ; Lloyd, A. W. ; Kozynchenko, O. P. ; Malik, D. J. ; Streat, M. ; Mikhalovsky, S. V. / Structural characteristics of activated carbons and ibuprofen adsorption affected by bovine serum albumin. In: Langmuir. 2004 ; Vol. 20, No. 7. pp. 2837-2851.
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