Structural characteristics of activated carbons and ibuprofen adsorption affected by bovine serum albumin

M. Melillo, V. M. Gun'ko, S. R. Tennison, L. I. Mikhalovska, G. J. Phillips, J. G. Davies, A. W. Lloyd, O. P. Kozynchenko, D. J. Malik, M. Streat, S. V. Mikhalovsky

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Abstract

Structural characteristics of a series of MAST carbons were studied using scanning electron microscopy images and the nitrogen adsorption isotherms analyzed with several models of pores and different adsorption equations. A developed model of pores as a mixture of gaps between spherical nanoparticles and slitlike pores was found appropriate for MAST carbons. Adsorption of ibuprofen [2-(4-isobutylphenyl)propionic acid] on activated carbons possessing different pore size distributions in protein-free and bovine serum albumin (BSA)-containing aqueous solutions reveals the importance of the contribution of mesopores to the total porosity of adsorbents. The influence of the mesoporosity increases when considering the removal of the drug from the protein-containing solution. Cellulose-coated microporous carbon Norit RBX adsorbs significantly smaller amounts of ibuprofen than uncoated micro/mesoporous MAST carbons whose adsorption capability increases with increasing mesoporosity and specific surface area, burnoff dependent variable. A similar effect of broad pores is observed on adsorption of fibrinogen on the same carbons. Analysis of the ibuprofen adsorption data using Langmuir and D'Arcy-Watt equations as the kernel of the Fredbolm integral equation shows that the nonuniformity of ibuprofen adsorption complexes diminishes with the presence of BSA. This effect may be explained by a partial adsorption of ibuprofen onto protein molecules immobilized on carbon particles and blocking of a portion of narrow pores.

Original languageEnglish
Pages (from-to)2837-2851
Number of pages15
JournalLangmuir
Volume20
Issue number7
DOIs
Publication statusPublished - Mar 30 2004

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ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

Melillo, M., Gun'ko, V. M., Tennison, S. R., Mikhalovska, L. I., Phillips, G. J., Davies, J. G., Lloyd, A. W., Kozynchenko, O. P., Malik, D. J., Streat, M., & Mikhalovsky, S. V. (2004). Structural characteristics of activated carbons and ibuprofen adsorption affected by bovine serum albumin. Langmuir, 20(7), 2837-2851. https://doi.org/10.1021/la0360557