TY - JOUR
T1 - Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)
AU - Xu, Pengfei
AU - Ianes, Chiara
AU - Gärtner, Fabian
AU - Liu, Congxing
AU - Burster, Timo
AU - Bakulev, Vasiliy
AU - Rachidi, N.
AU - Knippschild, Uwe
AU - Bischof, Joachim
N1 - Funding Information:
This review and the corresponding Gene Wiki article are written as part of the Gene Wiki Review series – a series resulting from a collaboration between the journal GENE and the Gene Wiki Initiative. The Gene Wiki Initiative is supported by National Institutes of Health (GM089820). Additional support for Gene Wiki Reviews is provided by Elsevier, the publisher of GENE. The authors would like to thank Martin Stöter for scientific and experimental input and discussion of data presented in chapter two.
Funding Information:
This work was supported by a grant to Uwe Knippschild from the Deutsche Forschungsgemeinschaft (DFG) [grant number KN356/9-1 ], a grant to Joachim Bischof from the Else Kröner-Fresenius-Stiftung [grant number 2017_A142 ], and a grant to Najma Rachidi [grant number ANR-13-ISV3-0009]. The sponsors had no influence on study design, analysis and interpretation of data, on the writing of the report, and on the decision to submit the article for publication.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/10/5
Y1 - 2019/10/5
N2 - Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well as mutations within their coding regions contribute to the development of various different pathologies, including cancer and neurodegenerative diseases, they have become interesting new drug targets within the last decade. However, to develop optimized CK1 isoform-specific therapeutics in personalized therapy concepts, a detailed knowledge of the regulation and functions of the different CK1 isoforms, their various splice variants and orthologs is mandatory. In this review we will focus on the stress-induced CK1 isoform delta (CK1δ), thereby addressing its regulation, physiological functions, the consequences of its deregulation for the development and progression of diseases, and its potential as therapeutic drug target.
AB - Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well as mutations within their coding regions contribute to the development of various different pathologies, including cancer and neurodegenerative diseases, they have become interesting new drug targets within the last decade. However, to develop optimized CK1 isoform-specific therapeutics in personalized therapy concepts, a detailed knowledge of the regulation and functions of the different CK1 isoforms, their various splice variants and orthologs is mandatory. In this review we will focus on the stress-induced CK1 isoform delta (CK1δ), thereby addressing its regulation, physiological functions, the consequences of its deregulation for the development and progression of diseases, and its potential as therapeutic drug target.
KW - Cancer
KW - Casein kinase 1
KW - CSNK1D
KW - Hedgehog pathway
KW - N
KW - P
KW - p53
KW - Phosphorylation
KW - R
KW - S
KW - Site-specific phosphorylation
KW - Small molecule inhibitor
KW - Stress-induced kinase
KW - Wnt signaling pathway
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U2 - 10.1016/j.gene.2019.144005
DO - 10.1016/j.gene.2019.144005
M3 - Review article
C2 - 31376410
AN - SCOPUS:85070576806
SN - 0378-1119
VL - 715
JO - Gene
JF - Gene
M1 - 144005
ER -
