Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)

Pengfei Xu, Chiara Ianes, Fabian Gärtner, Congxing Liu, Timo Burster, Vasiliy Bakulev, N. Rachidi, Uwe Knippschild, Joachim Bischof

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well as mutations within their coding regions contribute to the development of various different pathologies, including cancer and neurodegenerative diseases, they have become interesting new drug targets within the last decade. However, to develop optimized CK1 isoform-specific therapeutics in personalized therapy concepts, a detailed knowledge of the regulation and functions of the different CK1 isoforms, their various splice variants and orthologs is mandatory. In this review we will focus on the stress-induced CK1 isoform delta (CK1δ), thereby addressing its regulation, physiological functions, the consequences of its deregulation for the development and progression of diseases, and its potential as therapeutic drug target.

Original languageEnglish
Article number144005
JournalGene
Volume715
DOIs
Publication statusPublished - Oct 5 2019

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Keywords

  • Cancer
  • Casein kinase 1
  • CSNK1D
  • Hedgehog pathway
  • N
  • P
  • p53
  • Phosphorylation
  • R
  • S
  • Site-specific phosphorylation
  • Small molecule inhibitor
  • Stress-induced kinase
  • Wnt signaling pathway

ASJC Scopus subject areas

  • Genetics

Cite this

Xu, P., Ianes, C., Gärtner, F., Liu, C., Burster, T., Bakulev, V., Rachidi, N., Knippschild, U., & Bischof, J. (2019). Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D). Gene, 715, [144005]. https://doi.org/10.1016/j.gene.2019.144005