Synthesis and anodic electrochemistry of cymanquine and related complexes

Kevin Lam, William E. Geiger

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    9 Citations (Scopus)

    Abstract

    Three compounds have been prepared in which a 4-aminochloroquinoline moiety is covalently linked to a cyclopentadienyl manganese tricarbonyl moiety. One of these ("cymanquine", 4) is the analogue of the potent antimalarial drug ferroquine in which an FeCp group has been replaced by a Mn(CO)3 group. The anodic electrochemistry of the new compounds was investigated in dichloromethane, using [NBu4][B(C6F5)4] as the supporting electrolyte. Compared to ferroquine, oxidations of the new compounds occur at considerably more positive potentials and are highly irreversible, being located at their amine groups rather than at the organometallic center.

    Original languageEnglish
    Pages (from-to)15-20
    Number of pages6
    JournalJournal of Organometallic Chemistry
    Volume817
    DOIs
    Publication statusPublished - Aug 15 2016

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    Keywords

    • Anodic oxidation
    • Bioorganometallic
    • Chloroquinoline
    • Cymantrene
    • Ferroquine
    • Weakly coordinating anion

    ASJC Scopus subject areas

    • Inorganic Chemistry
    • Organic Chemistry
    • Physical and Theoretical Chemistry
    • Materials Chemistry
    • Biochemistry

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