Abstract
The reaction of 3-amino-4,6-dimethylpyridin-2(1H)-one and 3-amino-4-phenylpyridin-2-one with acyl isothiocyanates (benzoyl-, 4-bromobenzoyl-, and methacryloyl isothiocyanates) and with allyl isothiocyanate has been studied. The N-carbamothioyl methacrylamides and N-allylthioureas obtained undergo intramolecular heterocyclization reactions to give the corresponding 1,3-thiazin-4-one and 1,3-thiazoline derivatives. It was found that the starting 3-amino-4,6-dimethylpyridin-2(1H)-one shows antiradical activity but the synthesized thioureas do not.
Original language | English |
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Pages (from-to) | 670-676 |
Number of pages | 7 |
Journal | Chemistry of Heterocyclic Compounds |
Volume | 50 |
Issue number | 5 |
DOIs | |
Publication status | Published - Aug 2014 |
Keywords
- 1,3-thiazines
- 1,3-thiazolines
- 3-aminopyridin-2(1H)-ones
- intramolecular cyclization
- isothiocyanates
- thioureas
ASJC Scopus subject areas
- Organic Chemistry