Synthesis of cyclic sulfamides via one pot alkylation/aza-Michael cascade reaction

Sofia D. Martynova, Anatoly A. Peshkov, Ekaterina Yu. Levashova, Valeria M. Golub, Margarita S. Avakian, Vladimir V. Sharoyko, Stanislav A. Kalinin, Vsevolod A. Peshkov, Dmitry V. Dar'in

Research output: Contribution to journalArticlepeer-review

Abstract

A straightforward and transition metal-free method for the synthesis of cyclic sulfamides via base-promoted bis-alkylation of tert-butyl (N-alkylsulfamoyl)carbamates with electron-deficient allyl bromides is described. All obtained cyclic sulfamides underwent successful removal of tert-butoxycarbonyl protecting group.

Original languageEnglish
Article number155213
JournalTetrahedron Letters
Volume147
DOIs
Publication statusPublished - Sept 1 2024

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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