Synthesis of Diketones, Ketoesters, and Tetraketones by Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: Application to the Synthesis of cis-Jasmone

Xiaofeng Ma, Damien F. Dewez, Le Du, Xiya Luo, István E. Markó, Kevin Lam

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5 Citations (Scopus)

Abstract

Disubstituted malonic acid derivatives are smoothly converted into diketones and ketoesters in good to excellent yield (68% to 91%) under electrochemical conditions. The scope can be extended to transform trisubstituted bis-malonic acids into tetraketones in 77% to 86% yield. The new method was applied to the total synthesis of cis-jasmone.

Original languageEnglish
Pages (from-to)12044-12055
Number of pages12
JournalJournal of Organic Chemistry
Volume83
Issue number19
DOIs
Publication statusPublished - Oct 5 2018

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ASJC Scopus subject areas

  • Organic Chemistry

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