Abstract
An efficient one-pot protocol for the synthesis of isoquinolinium-2-yl amides starting from readily available hydrazides and 2-alkynylbenzaldehydes is described. The key step of the protocol is a silver(I)-catalyzed ring-closure of N-(2-alkynylbenzylidene)hydrazides that are generated in situ. Isoquinolinium-2-yl amides derived from tert-butoxycarbonyl hydrazide could be further deprotected, delivering 2-aminoisoquinolinium trifluoroacetates.
Original language | English |
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Article number | Z64411SS |
Pages (from-to) | 3371-3374 |
Number of pages | 4 |
Journal | Synthesis |
Issue number | 20 |
DOIs | |
Publication status | Published - Sep 12 2011 |
Externally published | Yes |
Keywords
- alkynes
- annulation
- hydrazides
- isoquinolines
- silver catalysis
- ylides
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry