Synthesis of the azocino[cd]indole framework through Pd-catalyzed intramolecular acetylene hydroarylation

Vsevolod A. Peshkov; Sofie Van Hove; Pavel A. Donets; Olga P. Pereshivko; Kristof Van Hecke; Luc Van Meervelt; Erik V. Van Der Eycken

doi:10.1002/ejoc.201001669

Synthesis of the azocino[cd]indole framework through Pd-catalyzed intramolecular acetylene hydroarylation

Vsevolod A. Peshkov, Sofie Van Hove, Pavel A. Donets, Olga P. Pereshivko, Kristof Van Hecke, Luc Van Meervelt, Erik V. Van Der Eycken

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

The regio- and stereoselective construction of the azocino[cd]indole core was achieved by applying a Pd-catalyzed intramolecular acetylene hydroarylation protocol. The applicability of a similar strategy for the synthesis of the azepino[b]indole framework is demonstrated.

Original language	English
Pages (from-to)	1837-1840
Number of pages	4
Journal	European Journal of Organic Chemistry
Issue number	10
DOIs	https://doi.org/10.1002/ejoc.201001669
Publication status	Published - Apr 1 2011
Externally published	Yes

Keywords

C-C coupling
Cyclization
Medium-ring compounds
Nitrogen heterocycles
Palladium

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

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10.1002/ejoc.201001669

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Synthesis of the azocino[cd]indole framework through Pd-catalyzed intramolecular acetylene hydroarylation. / Peshkov, Vsevolod A.; Van Hove, Sofie; Donets, Pavel A.; Pereshivko, Olga P.; Van Hecke, Kristof; Van Meervelt, Luc; Van Der Eycken, Erik V.

In: European Journal of Organic Chemistry, No. 10, 01.04.2011, p. 1837-1840.

Research output: Contribution to journal › Article › peer-review

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keywords = "C-C coupling, Cyclization, Medium-ring compounds, Nitrogen heterocycles, Palladium",

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AU - Peshkov, Vsevolod A.

AU - Van Hove, Sofie

AU - Donets, Pavel A.

AU - Pereshivko, Olga P.

AU - Van Hecke, Kristof

AU - Van Meervelt, Luc

AU - Van Der Eycken, Erik V.

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AB - The regio- and stereoselective construction of the azocino[cd]indole core was achieved by applying a Pd-catalyzed intramolecular acetylene hydroarylation protocol. The applicability of a similar strategy for the synthesis of the azepino[b]indole framework is demonstrated.

KW - C-C coupling

KW - Cyclization

KW - Medium-ring compounds

KW - Nitrogen heterocycles

KW - Palladium

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Synthesis of the azocino[cd]indole framework through Pd-catalyzed intramolecular acetylene hydroarylation

Abstract

Keywords

ASJC Scopus subject areas

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