Synthesis of the azocino[cd]indole framework through Pd-catalyzed intramolecular acetylene hydroarylation

Vsevolod A. Peshkov, Sofie Van Hove, Pavel A. Donets, Olga P. Pereshivko, Kristof Van Hecke, Luc Van Meervelt, Erik V. Van Der Eycken

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

The regio- and stereoselective construction of the azocino[cd]indole core was achieved by applying a Pd-catalyzed intramolecular acetylene hydroarylation protocol. The applicability of a similar strategy for the synthesis of the azepino[b]indole framework is demonstrated.

Original languageEnglish
Pages (from-to)1837-1840
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number10
DOIs
Publication statusPublished - Apr 1 2011
Externally publishedYes

Keywords

  • C-C coupling
  • Cyclization
  • Medium-ring compounds
  • Nitrogen heterocycles
  • Palladium

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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