Synthesis of Thiazolidine-2-thiones through a One-Pot A3-Coupling–Carbon Disulfide Incorporation Process

Anton A. Nechaev, Anatoly A. Peshkov, Kristof Van Hecke, Vsevolod A. Peshkov, Erik V. Van der Eycken

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A copper-catalyzed two-step one-pot procedure for the synthesis of thiazolidine-2-thiones has been developed. The process involves a three-component coupling of an alkyne, an aldehyde, and an amine (A3-coupling) followed by trapping the resulting propargylamine with carbon disulfide and subsequent cyclization.

Original languageEnglish
Pages (from-to)1063-1069
Number of pages7
JournalEuropean Journal of Organic Chemistry
Volume2017
Issue number6
DOIs
Publication statusPublished - Jan 1 2017
Externally publishedYes

Keywords

  • C1 building blocks
  • Cyclization
  • Heterocycles
  • Multicomponent reactions
  • Synthetic methods

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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