Synthesis of unsymmetrical tweezer receptor libraries and identification of receptors for Lys-D-Ala-D-Ala in aqueous solution

Jon Shepherd, Tom Gale, Kim B. Jensen, Jeremy D. Kilburn

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Libraries of "unsymmetrical" tweezer receptors, featuring a guanidinium head group as a carboxylate binding site and two independently synthesized peptidic arms, have been prepared and screened to identify receptors for the N-Ac-Lys-D-Ala-D-Ala tripeptide sequence. The binding properties of one such receptor structure, with dye-labeled N-Ac-Lys-D-Ala-D-Ala, were investigated. These studies demonstrated that when attached to the solid-phase, the receptor binds dyelabeled N-Ac-Lys-D-Ala-D-Ala, in buffered aqueous media, with ITIM binding affinity.

Original languageEnglish
Pages (from-to)713-720
Number of pages8
JournalChemistry - A European Journal
Volume12
Issue number3
DOIs
Publication statusPublished - Jan 11 2006

Keywords

  • Library
  • Peptides
  • Receptors
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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