Synthesis, steric structure, and biological activity of 5-methyl-2-(morpholin-4-ylamino)-5,6-dihydro-4H-1,3-thiazin-4-one

I. V. Kulakov, Z. T. Shulgau, K. M. Turdybekov, D. M. Turdybekov, D. T. Sadyrbekov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

New 5,6-dihydro-1,3-thiazin-4-one derivatives have been synthesized by one-pot reaction of morpholin-4-amine and adamantan-1-amine with methacryloyl isothiocyanate. Structure of 5-methyl-2-(morpholin-4-ylamino)-5,6-dihydro-4H-1,3-thiazin-4-one has been determined by X-ray analysis, and its high antiradical and anti-inflammatory activity has been revealed.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalRussian Journal of General Chemistry
Volume85
Issue number2
DOIs
Publication statusPublished - Feb 1 2015
Externally publishedYes

Keywords

  • 5,6-dihydro-1,3-thiazin-4-one
  • adamantan-1-amine
  • anti-inflammatory activity
  • antiradical activity
  • intramolecular cyclization
  • methacryloyl isothiocyanate
  • morpholin-4-amine

ASJC Scopus subject areas

  • Chemistry(all)

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