TY - JOUR
T1 - Synthetic amphoteric cryogels as an antidote against acute heavy metal poisoning
AU - Baimenov, Alzhan Z.
AU - Fakhradiyev, Ildar R.
AU - Berillo, Dmitriy A.
AU - Saliev, Timur
AU - Mikhalovsky, Sergey V.
AU - Nurgozhin, Talgat S.
AU - Inglezakis, Vassilis J.
N1 - Funding Information:
A.Z.B. acknowledges a postdoctoral fellowship from the al-Farabi Kazakh
Funding Information:
Funding: The current work was financially supported by a state grant for PhD students by the Ministry of Education and Science of Kazakhstan (MES RK). It was also partially funded by the HORIZON 2020 project H2020-MSCA-RISE-2016 “Nanoporous and Nanostructured Materials for Medical Applications (NanoMed)”, (grant number: 734641).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - The effectiveness of an amphoteric cryogel (AAC) as an oral sorbent (enerosorbent) for the treatment of acute poisoning of small animals (rats) with heavy metals (HMs) was studied in in vivo experiments. The morphological structure of the cryogel was examined using scanning electron microscopy/energy-dispersive X-ray analysis and confocal microscopy. The use of the cryogel in the treatment of rats administered an LD50 dose of Cd(NO3 )2, CsNO3, Sr(NO3)2, or HgCl2 in aqueous solution showed their high survival rate compared to the control group, which did not receive such treatment. The histological and chemical analysis of internal tissues and the biochemical analysis of the blood of the experimental animals showed the effectiveness of the cryogel in protecting the animals against the damaging effect of HMs on the organism comparable with unithiol, a chelating agent based on 2,3-dimercapto-1-propane sulfonic acid sodium salt (DMPS) approved for the treatment of acute poisoning with some heavy metals.
AB - The effectiveness of an amphoteric cryogel (AAC) as an oral sorbent (enerosorbent) for the treatment of acute poisoning of small animals (rats) with heavy metals (HMs) was studied in in vivo experiments. The morphological structure of the cryogel was examined using scanning electron microscopy/energy-dispersive X-ray analysis and confocal microscopy. The use of the cryogel in the treatment of rats administered an LD50 dose of Cd(NO3 )2, CsNO3, Sr(NO3)2, or HgCl2 in aqueous solution showed their high survival rate compared to the control group, which did not receive such treatment. The histological and chemical analysis of internal tissues and the biochemical analysis of the blood of the experimental animals showed the effectiveness of the cryogel in protecting the animals against the damaging effect of HMs on the organism comparable with unithiol, a chelating agent based on 2,3-dimercapto-1-propane sulfonic acid sodium salt (DMPS) approved for the treatment of acute poisoning with some heavy metals.
KW - Antidote
KW - Cryogel
KW - DMPS
KW - Elimination
KW - Heavy metals
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U2 - 10.3390/molecules26247601
DO - 10.3390/molecules26247601
M3 - Article
AN - SCOPUS:85121572010
VL - 26
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 24
M1 - 7601
ER -