T-CELL INDUCERS OF SUPPRESSOR LYMPHOCYTES CONTROL LIVER-DIRECTED AUTOREACTIVITY

Sandro Vento; Ian G. Mcfarlane; Charles J. O'Brien; Roger Williams; Adrian L.W.F. Eddleston

doi:10.1016/S0140-6736(87)92860-1

T-CELL INDUCERS OF SUPPRESSOR LYMPHOCYTES CONTROL LIVER-DIRECTED AUTOREACTIVITY

Sandro Vento, Ian G. Mcfarlane, Charles J. O'Brien, Roger Williams, Adrian L.W.F. Eddleston

Department of Medicine

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The sensitisation of helper T cells of patients with autoimmune chronic active hepatitis to a liver-cell membrane-expressed asialoglycoprotein receptor protein is shown to be associated with a defect of T cells that specifically induce suppressor lymphocytes. These lymphocytes are found in an activated state in the peripheral blood of healthy people and may form part of an immunoregulatory network which actively prevents autoimmunity.

Original language	English
Pages (from-to)	886-888
Number of pages	3
Journal	The Lancet
Volume	329
Issue number	8538
DOIs	https://doi.org/10.1016/S0140-6736(87)92860-1
Publication status	Published - Apr 18 1987

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(87)92860-1

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abstract = "The sensitisation of helper T cells of patients with autoimmune chronic active hepatitis to a liver-cell membrane-expressed asialoglycoprotein receptor protein is shown to be associated with a defect of T cells that specifically induce suppressor lymphocytes. These lymphocytes are found in an activated state in the peripheral blood of healthy people and may form part of an immunoregulatory network which actively prevents autoimmunity.",

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AU - Williams, Roger

AU - Eddleston, Adrian L.W.F.

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