T-CELL INDUCERS OF SUPPRESSOR LYMPHOCYTES CONTROL LIVER-DIRECTED AUTOREACTIVITY

Sandro Vento, Ian G. Mcfarlane, Charles J. O'Brien, Roger Williams, Adrian L.W.F. Eddleston

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The sensitisation of helper T cells of patients with autoimmune chronic active hepatitis to a liver-cell membrane-expressed asialoglycoprotein receptor protein is shown to be associated with a defect of T cells that specifically induce suppressor lymphocytes. These lymphocytes are found in an activated state in the peripheral blood of healthy people and may form part of an immunoregulatory network which actively prevents autoimmunity.

Original languageEnglish
Pages (from-to)886-888
Number of pages3
JournalThe Lancet
Volume329
Issue number8538
DOIs
Publication statusPublished - Apr 18 1987

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Vento, S., Mcfarlane, I. G., O'Brien, C. J., Williams, R., & Eddleston, A. L. W. F. (1987). T-CELL INDUCERS OF SUPPRESSOR LYMPHOCYTES CONTROL LIVER-DIRECTED AUTOREACTIVITY. The Lancet, 329(8538), 886-888. https://doi.org/10.1016/S0140-6736(87)92860-1