Abstract
Tamm-Horsfall Protein (THP) is found to be localised in the ascending loop of Henle and the distal tubules of normal and foetal kidneys. We have used an anti-THP monoclonal antibody (D2) to stain foetal, normal and kidney tumours. The dinitrophenyl hapten staining technique was the most specific and sensitive staining procedure. The staining of Tamm-Horsfall Protein in foetal and normal kidney was in agreement with most other investigators. The majority of renal cell carcinoma (22/24) and rhabdoid renal tumours (3/4) stained positively for THP. None of the Wilms' tumours, mesoblastic nephromas or bone metastasising renal tumours of childhood gave positive staining. The findings would suggest that renal cell carcinomas and rhabdoid kidney tumours arise from ascending loop of Henle or distal tubules. The lack of positive staining in the majority of childhood renal tumours raises the possibility of a different histogenesis for these neoplasms.
| Original language | English |
|---|---|
| Pages (from-to) | 2159-2161 |
| Number of pages | 3 |
| Journal | Anticancer Research |
| Volume | 11 |
| Issue number | 6 |
| Publication status | Published - 1991 |
| Externally published | Yes |
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Keywords
- Kidney tumours
- Normal kidneys
- Tamm-Horsfall protein
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Tamm-Horsfall protein in human renal tumours. / Costello, C. B.; Jasani, B.; Kumar, S.
In: Anticancer Research, Vol. 11, No. 6, 1991, p. 2159-2161.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tamm-Horsfall protein in human renal tumours
AU - Costello, C. B.
AU - Jasani, B.
AU - Kumar, S.
PY - 1991
Y1 - 1991
N2 - Tamm-Horsfall Protein (THP) is found to be localised in the ascending loop of Henle and the distal tubules of normal and foetal kidneys. We have used an anti-THP monoclonal antibody (D2) to stain foetal, normal and kidney tumours. The dinitrophenyl hapten staining technique was the most specific and sensitive staining procedure. The staining of Tamm-Horsfall Protein in foetal and normal kidney was in agreement with most other investigators. The majority of renal cell carcinoma (22/24) and rhabdoid renal tumours (3/4) stained positively for THP. None of the Wilms' tumours, mesoblastic nephromas or bone metastasising renal tumours of childhood gave positive staining. The findings would suggest that renal cell carcinomas and rhabdoid kidney tumours arise from ascending loop of Henle or distal tubules. The lack of positive staining in the majority of childhood renal tumours raises the possibility of a different histogenesis for these neoplasms.
AB - Tamm-Horsfall Protein (THP) is found to be localised in the ascending loop of Henle and the distal tubules of normal and foetal kidneys. We have used an anti-THP monoclonal antibody (D2) to stain foetal, normal and kidney tumours. The dinitrophenyl hapten staining technique was the most specific and sensitive staining procedure. The staining of Tamm-Horsfall Protein in foetal and normal kidney was in agreement with most other investigators. The majority of renal cell carcinoma (22/24) and rhabdoid renal tumours (3/4) stained positively for THP. None of the Wilms' tumours, mesoblastic nephromas or bone metastasising renal tumours of childhood gave positive staining. The findings would suggest that renal cell carcinomas and rhabdoid kidney tumours arise from ascending loop of Henle or distal tubules. The lack of positive staining in the majority of childhood renal tumours raises the possibility of a different histogenesis for these neoplasms.
KW - Kidney tumours
KW - Normal kidneys
KW - Tamm-Horsfall protein
UR - http://www.scopus.com/inward/record.url?scp=0026341410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026341410&partnerID=8YFLogxK
M3 - Article
VL - 11
SP - 2159
EP - 2161
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 6
ER -