Tamm-Horsfall protein is a marker of renal and extra-renal rhabdoid tumours

S. Kumar, S. M. Jakate, H. B. Marsden, P. Kumar, B. Jasani

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A monoclonal antibody (MAb) to Tamm-Horsfall protein (THP) was used to stain 6 renal rhabdoid tumours (RRT) and 2 primary extra-renal rhabdoid tumours (E-RRT). One of the E-RRT was a tumour from the posterior fossa of a 3-year-old child and the other was a lump from the right side of the neck in an 18-month-old girl. Five of 6 RRT and both cases of E-RRT were positive for THP. Both cases of E-RRT also reacted with vimentin and cytokeratin MAbs. On electron microscopy, cells from both E-RRT were seen to contain concentric whorls of intermediate filaments characteristic of rhabdoid tumours. Viable tissues from one RRt and one E-RRT (the posterior fossa tumour) were available for tissue culture. Ninety-five percent of the cells growing out of both tumours were polygonal and approximately 5% of these cells were THP-positive.

Original languageEnglish
Pages (from-to)386-389
Number of pages4
JournalInternational Journal of Cancer
Volume41
Issue number3
Publication statusPublished - 1988
Externally publishedYes

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Uromodulin
Rhabdoid Tumor
Kidney
Infratentorial Neoplasms
Intermediate Filaments
Vimentin
Keratins
Electron Microscopy
Coloring Agents
Neck
Monoclonal Antibodies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kumar, S., Jakate, S. M., Marsden, H. B., Kumar, P., & Jasani, B. (1988). Tamm-Horsfall protein is a marker of renal and extra-renal rhabdoid tumours. International Journal of Cancer, 41(3), 386-389.

Tamm-Horsfall protein is a marker of renal and extra-renal rhabdoid tumours. / Kumar, S.; Jakate, S. M.; Marsden, H. B.; Kumar, P.; Jasani, B.

In: International Journal of Cancer, Vol. 41, No. 3, 1988, p. 386-389.

Research output: Contribution to journalArticle

Kumar, S, Jakate, SM, Marsden, HB, Kumar, P & Jasani, B 1988, 'Tamm-Horsfall protein is a marker of renal and extra-renal rhabdoid tumours', International Journal of Cancer, vol. 41, no. 3, pp. 386-389.
Kumar S, Jakate SM, Marsden HB, Kumar P, Jasani B. Tamm-Horsfall protein is a marker of renal and extra-renal rhabdoid tumours. International Journal of Cancer. 1988;41(3):386-389.
Kumar, S. ; Jakate, S. M. ; Marsden, H. B. ; Kumar, P. ; Jasani, B. / Tamm-Horsfall protein is a marker of renal and extra-renal rhabdoid tumours. In: International Journal of Cancer. 1988 ; Vol. 41, No. 3. pp. 386-389.
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