TANTIGEN 2.0: An online database and analysis platform for tumor T cell antigens

Guanglan Zhang, Lou Chitkushev, Derin B. Keskin, Vladimir Brusic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We previously developed TANTIGEN, a comprehensive web-based database cataloging more than 1,000 T cell epitopes and HLA ligands from 292 tumor antigens. TANTIGEN 2.0 is significantly expanded the number and coverage of immune response targets (T cell epitopes and HLA ligands) of previously cataloged tumor antigens. We expanded the number of cataloged tumor antigens to more than 4,000 and have added their reported targets of immune responses. We also included neoantigens, a new class of tumor antigens generated through mutations that results in a new amino acid sequence in tumor antigens. TANTIGEN 2.0 contains validated TCR sequences specific for cognate T cell epitopes. Gene expression information was extracted from tumor antigen gene/mRNA/protein expression information in major human cancers provided by Human Pathology Atlas. TANTIGEN 2.0 provides a rich data resource for tumor-associated epitope and neoepitope discovery studies. It is freely available at http://projects.met-hilab.org/tadb.

Original languageEnglish
Title of host publicationProceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019
EditorsIllhoi Yoo, Jinbo Bi, Xiaohua Tony Hu
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2228-2231
Number of pages4
ISBN (Electronic)9781728118673
DOIs
Publication statusPublished - Nov 2019
Externally publishedYes
Event2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019 - San Diego, United States
Duration: Nov 18 2019Nov 21 2019

Publication series

NameProceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019

Conference

Conference2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019
CountryUnited States
CitySan Diego
Period11/18/1911/21/19

Keywords

  • T cell epitope prediction
  • cancer vaccine
  • immunotherapy
  • neoantigen
  • neoepitope
  • tumor antigen

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Molecular Medicine
  • Modelling and Simulation
  • Health Informatics
  • Pharmacology (medical)
  • Public Health, Environmental and Occupational Health

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