Temporal and antigenic analysis of dengue virus serotype 1 genome polyprotein sequences

Menaka Rajapakse, Anitha Veeramani, Kavitha Gopalakrishnan, Sivagami Ananthanarayan, Asif M. Khan, K. N. Srinivasan, J. Thomas August, Vladimir Brusic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dengue virus poses a significant health threat. The new emerging strains continue to cause annual epidemics. In this paper, we report results of an analysis of dengue virus serotype 1 (DV1) genome polyprotein sequences in the context of time and geographical distribution. We studied the clustering of 60 DV1 genome polyprotein sequences of different geographical distributions, reported in the past 30 years, to identify geographic and temporal patterns of genetic and antigenic variation. Our analysis showed distinct clustering of sequences into two main geographical regions: i) Western and South Pacific and South-East Asian region (with three distinct sub-clusters) and ii) South American region. The results provide evidence suggesting temporal changes of the isolated strains. In addition, our analysis indicated that potential T-cell epitope hotspots within DV1 are shifting with time and recurrent epidemics, resulting in disappearing of some hotspots and emerging of new hotspots.

Original languageEnglish
Title of host publicationICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering
Pages301-306
Number of pages6
DOIs
Publication statusPublished - Dec 1 2006
EventICBPE 2006 - 2006 International Conference on Biomedical and Pharmaceutical Engineering - Singapore, Singapore
Duration: Dec 11 2006Dec 14 2006

Publication series

NameICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering

Other

OtherICBPE 2006 - 2006 International Conference on Biomedical and Pharmaceutical Engineering
CountrySingapore
CitySingapore
Period12/11/0612/14/06

Keywords

  • Dengue virus
  • Geographic
  • Human leukocyte antigen
  • Serotype
  • Supertype
  • T-cell epitope hotspots
  • Temporal

ASJC Scopus subject areas

  • Biomedical Engineering
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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