TY - JOUR
T1 - Terbium-doped carbon dots (Tb-CDs) as a novel contrast agent for efficient X-ray attenuation
AU - Molkenova, Anara
AU - Serik, Lazzat
AU - Ramazanova, Alina
AU - Zhumanova, Kamila
AU - Duisenbayeva, Bakyt
AU - Zhussupbekova, Ainur
AU - Zhussupbekov, Kuanysh
AU - Shvets, Igor V.
AU - Kim, Ki Su
AU - Han, Dong Wook
AU - Atabaev, Timur Sh
N1 - Funding Information:
This study was financially supported by the 2022 Post-Doc. Development Program of Pusan National University. This work was implemented within the National Research Foundation of Korea (NRF) grant supported by the Korean government (the Ministry of Science and ICT) (No. 2022R1C1C1009533 and 2021M3H4A4079509) and a grant (HF21C0156) of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea. A. Z. and K. Z. would like to acknowledge funding from IRC through GOIPD/2022/443 and GOIPD/2022/774 awards.
Publisher Copyright:
© 2023 The Royal Society of Chemistry.
PY - 2023/6
Y1 - 2023/6
N2 - Metal-doped carbon dots have attracted considerable attention in nanomedicine over the last decade owing to their high biocompatibility and great potential for bioimaging, photothermal therapy, and photodynamic therapy. In this study, we prepared, and for the first time, examined terbium-doped CDs (Tb-CDs) as a novel contrast agent for computed tomography. A detailed physicochemical analysis revealed that the prepared Tb-CDs have small sizes (∼2-3 nm), contain relatively high terbium concentration (∼13.3 wt%), and exhibit excellent aqueous colloidal stability. Furthermore, preliminary cell viability and CT measurements suggested that Tb-CDs exhibit negligible cytotoxicity toward L-929 cells and demonstrate high X-ray absorption performance (∼48.2 ± 3.9 HU L g−1). Based on these findings, the prepared Tb-CDs could serve as a promising contrast agent for efficient X-ray attenuation.
AB - Metal-doped carbon dots have attracted considerable attention in nanomedicine over the last decade owing to their high biocompatibility and great potential for bioimaging, photothermal therapy, and photodynamic therapy. In this study, we prepared, and for the first time, examined terbium-doped CDs (Tb-CDs) as a novel contrast agent for computed tomography. A detailed physicochemical analysis revealed that the prepared Tb-CDs have small sizes (∼2-3 nm), contain relatively high terbium concentration (∼13.3 wt%), and exhibit excellent aqueous colloidal stability. Furthermore, preliminary cell viability and CT measurements suggested that Tb-CDs exhibit negligible cytotoxicity toward L-929 cells and demonstrate high X-ray absorption performance (∼48.2 ± 3.9 HU L g−1). Based on these findings, the prepared Tb-CDs could serve as a promising contrast agent for efficient X-ray attenuation.
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U2 - 10.1039/d3ra00958k
DO - 10.1039/d3ra00958k
M3 - Article
AN - SCOPUS:85159781500
SN - 2046-2069
VL - 13
SP - 14974
EP - 14979
JO - RSC Advances
JF - RSC Advances
ER -