Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10

C. Claus Stolt, Stephan Rehberg, Marius Ader, Petra Lommes, Dieter Riethmacher, Melitta Schachner, Udo Bartsch, Michael Wegner

Research output: Contribution to journalArticle

426 Citations (Scopus)

Abstract

Sox10 is a high-obility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalGenes and Development
Volume16
Issue number2
DOIs
Publication statusPublished - Jan 15 2002

Keywords

  • Glial cells
  • HMG
  • MBP
  • Neuregulin
  • PLP
  • Sox

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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  • Cite this

    Claus Stolt, C., Rehberg, S., Ader, M., Lommes, P., Riethmacher, D., Schachner, M., Bartsch, U., & Wegner, M. (2002). Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes and Development, 16(2), 165-170. https://doi.org/10.1101/gad.215802