The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro

D. Qualtrough, K. Singh, N. Banu, C. Paraskeva, M. Pignatelli

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. Methods: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed. Results: We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection. Conclusion: These data suggest an important role for fascin in the malignant progression of colorectal tumours.

Original languageEnglish
Pages (from-to)1124-1129
Number of pages6
JournalBritish Journal of Cancer
Volume101
Issue number7
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Adenoma
Actins
Proteins
Cell Movement
Colorectal Neoplasms
Transfection
In Vitro Techniques
fascin
Cell Line
Neoplasms

Keywords

  • Adenoma
  • Colon
  • Fascin
  • Migration

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro. / Qualtrough, D.; Singh, K.; Banu, N.; Paraskeva, C.; Pignatelli, M.

In: British Journal of Cancer, Vol. 101, No. 7, 2009, p. 1124-1129.

Research output: Contribution to journalArticle

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AU - Singh, K.

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AU - Pignatelli, M.

PY - 2009

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