The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro

D. Qualtrough, K. Singh, N. Banu, C. Paraskeva, M. Pignatelli

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. Methods: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed. Results: We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection. Conclusion: These data suggest an important role for fascin in the malignant progression of colorectal tumours.

Original languageEnglish
Pages (from-to)1124-1129
Number of pages6
JournalBritish journal of cancer
Volume101
Issue number7
DOIs
Publication statusPublished - Sep 9 2009

Keywords

  • Adenoma
  • Colon
  • Fascin
  • Migration

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro'. Together they form a unique fingerprint.

  • Cite this