Abstract
Background: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. Methods: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed. Results: We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection. Conclusion: These data suggest an important role for fascin in the malignant progression of colorectal tumours.
Original language | English |
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Pages (from-to) | 1124-1129 |
Number of pages | 6 |
Journal | British journal of cancer |
Volume | 101 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2009 |
Externally published | Yes |
Keywords
- Adenoma
- Colon
- Fascin
- Migration
ASJC Scopus subject areas
- Oncology
- Cancer Research