The Application of Multicomponent Ugi and Passerini Reactions for the One-Pot Synthesis of Pyrrolones and Butenolides

Anton A. Nechaev, Anatoly A. Peshkov, Vsevolod A. Peshkov, Erik V. Van Der Eycken

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

A new protocol for the one-pot synthesis of pyrrolones and butenolides involving an isocyanide-based multicomponent reaction (Ugi or Passerini) followed by a triethylamine-promoted cycloisomerization is described.

Original languageEnglish
Article numberss-2016-t0067-op
Pages (from-to)2280-2286
Number of pages7
JournalSynthesis (Germany)
Volume48
Issue number14
DOIs
Publication statusPublished - Jul 15 2016
Externally publishedYes

Keywords

  • butenolide
  • ethyl glyoxylate
  • Passerini reaction
  • propiolic acid
  • pyrrolone
  • Ugi reaction

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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