The diagnostic value of earlier and later components of Vestibular Evoked Myogenic Potentials (VEMP) in Multiple Sclerosis

A. Eleftheriadou, S. N. Deftereos, V. Zarikas, G. Panagopoulos, S. Sfetsos, C. L. Karageorgiou, E. Ferekidou, D. Kandiloros, S. Korres

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Aim of the study: To evaluate the ability of VEMP to disclose spatial dissemination of Multiple Sclerosis. Materials and methods: Forty-six MS patients with auditory and /or vestibular symptoms were studied. Patients were divided in two groups. Group 1 included 24 patients with brainstem MRI findings, and Group 2 included 22 patients without MRI findings. VEMP and BAEP have been recorded and assessed. Results: Abnormal p13n23 wave was observed in 50%, while unilateral absence or bilateral delay of the n34p44 in 43% of the patients. The overall diagnostic value considering abnormal cases suggested by both first and second VEMP waves was increased to 71%. Statistically significant differences revealed between patients and controls for p13 latency (p=0.018). The p13n23 was abnormal in 7 patients, although MRI scanning did not reveal brainstem lesions. {I}n 9 out of 18 MS patients suffering from unilateral hearing loss, n34p44 was present in the unaffected ears and absent in the affected side, although p13n23 was normal. Conclusion: Abnormal VEMP imply the presence of lesions undetected by MRI neuroimaging, which verifies the diagnostic value of the method. Unilateral absence of n34p44 complex was related with sensorineural hearing loss, supporting the hypothesis that n34p44 is of cochlear origin.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalJournal of Vestibular Research: Equilibrium and Orientation
Volume19
Issue number1-2
DOIs
Publication statusPublished - 2009
Externally publishedYes

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Vestibular Evoked Myogenic Potentials
Multiple Sclerosis
Brain Stem
Unilateral Hearing Loss
Sensorineural Hearing Loss
Cochlea
Neuroimaging
Ear

Keywords

  • BAEP
  • MS
  • N34-p44
  • VEMP

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology
  • Sensory Systems
  • Neuroscience(all)

Cite this

The diagnostic value of earlier and later components of Vestibular Evoked Myogenic Potentials (VEMP) in Multiple Sclerosis. / Eleftheriadou, A.; Deftereos, S. N.; Zarikas, V.; Panagopoulos, G.; Sfetsos, S.; Karageorgiou, C. L.; Ferekidou, E.; Kandiloros, D.; Korres, S.

In: Journal of Vestibular Research: Equilibrium and Orientation, Vol. 19, No. 1-2, 2009, p. 59-66.

Research output: Contribution to journalArticle

Eleftheriadou, A, Deftereos, SN, Zarikas, V, Panagopoulos, G, Sfetsos, S, Karageorgiou, CL, Ferekidou, E, Kandiloros, D & Korres, S 2009, 'The diagnostic value of earlier and later components of Vestibular Evoked Myogenic Potentials (VEMP) in Multiple Sclerosis', Journal of Vestibular Research: Equilibrium and Orientation, vol. 19, no. 1-2, pp. 59-66. https://doi.org/10.3233/VES-2009-0342
Eleftheriadou, A. ; Deftereos, S. N. ; Zarikas, V. ; Panagopoulos, G. ; Sfetsos, S. ; Karageorgiou, C. L. ; Ferekidou, E. ; Kandiloros, D. ; Korres, S. / The diagnostic value of earlier and later components of Vestibular Evoked Myogenic Potentials (VEMP) in Multiple Sclerosis. In: Journal of Vestibular Research: Equilibrium and Orientation. 2009 ; Vol. 19, No. 1-2. pp. 59-66.
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