The E-cadherin/epidermal growth factor receptor interaction

A hypothesis of reciprocal and reversible control of intercellular adhesion and cell proliferation

Aida U. Jawhari, Michael J G Farthing, Massimo Pignatelli

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The E-cadherin/catenin complex is a calcium-dependent cell-cell adhesion molecule, whose function is critical to the integrity of the adherens junction and which plays a role in the establishment and maintenance of normal epithelial morphology and differentiation. Loss of E-cadherin-mediated adhesion appears to be a fundamental aspect of the neoplastic phenotype which in some cases appears to be mediated by post-translational modifications (i.e. tyrosine phosphorylation) of its interacting proteins, the catenins which link E-cadherin to the actin cytoskeleton. There is increasing experimental evidence to suggest that epidermal growth factor receptor tyrosine phosphorylation may lead to the inactivation of the E- cadherin/catenin complex in cancer cells through its interaction with β- or γ-catenin in the cytoskeleton. Modulation of epidermal growth factor receptor activity by pharmacological agents has the potential to regulate a variety of cellular processes including adhesion, differentiation, and proliferation.

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalJournal of Pathology
Volume187
Issue number2
DOIs
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Catenins
Cadherins
Epidermal Growth Factor Receptor
Cell Proliferation
Tyrosine
Phosphorylation
Adherens Junctions
Cell Adhesion Molecules
Post Translational Protein Processing
Cytoskeleton
Actin Cytoskeleton
Maintenance
Pharmacology
Calcium
Phenotype
Neoplasms

Keywords

  • Cell adhesion molecule
  • E-cadherin
  • EGFR
  • Epidermal growth factor receptor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The E-cadherin/epidermal growth factor receptor interaction : A hypothesis of reciprocal and reversible control of intercellular adhesion and cell proliferation. / Jawhari, Aida U.; Farthing, Michael J G; Pignatelli, Massimo.

In: Journal of Pathology, Vol. 187, No. 2, 1999, p. 155-157.

Research output: Contribution to journalArticle

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