The effect of chronic ultraviolet radiation on the human immune system

Mary Norval, Pauline McLoone, Aleksandra Lesiak, Joanna Narbutt

Research output: Contribution to journalArticle

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Abstract

A single or a limited number of UVR exposures is recognized to suppress cell-mediated immunity in human subjects. The complex pathway leading from the absorption of photons by chromophores in the skin to the generation of T regulatory cells has been, at least partially, elucidated. However, the effect of repeated UV exposures on immune responses and associated mediators is not well studied, particularly to assess whether they lead, first, to the development of photoprotection so that these immune changes are reduced or no longer occur, and, secondly, to the development of photoprotection against the normal downregulation of immunity induced by a high UV dose. For almost all the parameters evaluated in this review - epidermal DNA damage/erythema, urocanic acid, Langerhans and dendritic cells, natural killer cells, macrophages, mast cells, contact and delayed hypersensitivity responses - none, aside from epidermal DNA damage/erythema and macrophage phagocytic activity, show convincing evidence of photoadaptation or, where appropriate, photoprotection. It is concluded that repeatedly irradiating individuals with UVR is likely to continue to result in downregulation of immunity.

LanguageEnglish
Pages19-28
Number of pages10
JournalPhotochemistry and Photobiology
Volume84
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

immune systems
Macrophages
Immune system
Erythema
Ultraviolet radiation
ultraviolet radiation
DNA Damage
Immune System
Immunity
immunity
Down-Regulation
Urocanic Acid
Radiation
macrophages
Langerhans Cells
DNA
Contact Dermatitis
Delayed Hypersensitivity
Regulatory T-Lymphocytes
Chromophores

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics

Cite this

The effect of chronic ultraviolet radiation on the human immune system. / Norval, Mary; McLoone, Pauline; Lesiak, Aleksandra; Narbutt, Joanna.

In: Photochemistry and Photobiology, Vol. 84, No. 1, 01.2008, p. 19-28.

Research output: Contribution to journalArticle

Norval, Mary ; McLoone, Pauline ; Lesiak, Aleksandra ; Narbutt, Joanna. / The effect of chronic ultraviolet radiation on the human immune system. In: Photochemistry and Photobiology. 2008 ; Vol. 84, No. 1. pp. 19-28
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