The effect of psychological distress on IVF outcomes: Reality or speculations?

Gulzhanat Aimagambetova, Alpamys Issanov, Sanja Terzic, Gauri Bapayeva, Talshyn Ukybassova, Saltanat Baikoshkarova, Aidana Aldiyarova, Fariza Shauyen, Milan Terzic

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


INTRODUCTION: Infertility is a problem that affects millions of people worldwide. The aim of this study was to assess the effect of stress, depression and anxiety on the IVF outcomes in Kazakhstan.

METHODS: The prospective cohort study was performed using questionnaires to assess psychological distress in 304 infertile female in three different cities in Kazakhstan.

RESULTS: The average age of participants was 33.7 years with infertility duration of 5.9 years. Regarding stress, depression and anxiety we found that more than 80% of all respondents had CES-D score higher than 16, indicating that they are at risk of developing clinical depression. On average, FPI subscales' scores, global stress score and anxiety scale (STAI-S and STAI-T) scores were statistically significantly higher among not pregnant women than pregnant women. Similarly, in simple logistic regression analysis all FPI subscales scores, global stress scale score and anxiety scales' scores were negatively associated with clinical pregnancy.

CONCLUSION: Rates of stress, anxiety and depression among IVF patients are higher than in general population. If the level of infertility-related stress is higher, IVF success rate is lower. Findings of our study indicate the need for the specific psychological interventions for all infertility women, to improve IVF success rate.

Original languageEnglish
Pages (from-to)e0242024
JournalPLoS ONE
Issue number12
Publication statusPublished - 2020


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