The emergence of an unassigned complex recombinant form in a Pakistani HIV-infected individual

Uroosa Tariq, Ayesha Iftikhar, Dilsha Zahid, Faisal Sultan, Syed Faisal Mahmood, Sadaf Naeem, Syed Ali, Syed Hani Abidi

Research output: Contribution to journalArticle

Abstract

In Pakistan, the HIV situation has gone from an outbreak to a concentrated epidemic, and the virus has now crossed into the low-risk population. In addition, several new HIV outbreaks have occurred in different parts of the country. HIV-1 subtype A has been the major epidemic subtype in Pakistan; however, as the epidemic has grown, the emergence of several new subtypes and recombinant forms has been observed. Here, we present the first case and genetic analysis of an unassigned, complex recombinant form in a Pakistani HIV-infected individual with virological failure. Genetic analysis of the sequence indicated that this recombinant form is multi-drug resistant, harboring drug resistance mutations against more than one class of antiretroviral drugs.

Original languageEnglish
Pages (from-to)967-972
Number of pages6
JournalArchives of Virology
Volume165
Issue number4
DOIs
Publication statusPublished - Apr 1 2020

ASJC Scopus subject areas

  • Virology

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    Tariq, U., Iftikhar, A., Zahid, D., Sultan, F., Mahmood, S. F., Naeem, S., Ali, S., & Abidi, S. H. (2020). The emergence of an unassigned complex recombinant form in a Pakistani HIV-infected individual. Archives of Virology, 165(4), 967-972. https://doi.org/10.1007/s00705-020-04551-4