The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system

Stefan Britsch, Li Li, Susanne Kirchhoff, Franz Theuring, Volker Brinkmann, Carmen Birchmeier, Dieter Riethmacher

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

Neuregulins (NDF, heregulin, GGF ARIA, or SMDF) are EGF-like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family. Here, we report a novel phenotype in mice with targeted mutations in the erbB2, erbB3, or neuregulin-1 genes. These three mutations cause a severe hypoplasia of the primary sympathetic ganglion chain. We provide evidence that migration of neural crest cells to the mesenchyme lateral of the dorsal aorta, in which they differentiate into sympathetic neurons, depends on neuregulin-1 and its receptors. Neuregulin-1 is expressed at the origin of neural crest cells. Moreover, a tight link between neuregulin-1 expression, the migratory path, and the target site of sympathogenic neural crest cells is observed. Sympathetic ganglia synthesize catecholamines in the embryo and the adult. Accordingly, catecholamine levels in mutant embryos are severely decreased, and we suggest that the lack of catecholamines contributes to the embryonal lethality of the erbB3 mutant mice. Thus, neuregulin-1, erbB2, and erbB3 are required for the formation of the sympathetic nervous system; the block in development observed in mutant mice is caused by a lack of neural crest precursor cells in the anlage of the primary sympathetic ganglion chain. Together with previous observations, these findings establish the neuregulin signaling system as a key regulator in the development of neural crest cells.

Original languageEnglish
Pages (from-to)1825-1836
Number of pages12
JournalGenes and Development
Volume12
Issue number12
Publication statusPublished - Jun 15 1998
Externally publishedYes

Fingerprint

Neuregulin-1
Sympathetic Nervous System
Neural Crest
Ligands
Sympathetic Ganglia
Neuregulins
Catecholamines
Embryonic Structures
Growth Differentiation Factors
Mutation
Receptor Protein-Tyrosine Kinases
Mesoderm
Epidermal Growth Factor
Aorta
Phenotype
Neurons
Genes

Keywords

  • Adrenal medulla
  • Catecholamines
  • Development
  • Migration
  • Neural crest cells
  • Tyrosine kinase receptor

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Britsch, S., Li, L., Kirchhoff, S., Theuring, F., Brinkmann, V., Birchmeier, C., & Riethmacher, D. (1998). The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes and Development, 12(12), 1825-1836.

The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. / Britsch, Stefan; Li, Li; Kirchhoff, Susanne; Theuring, Franz; Brinkmann, Volker; Birchmeier, Carmen; Riethmacher, Dieter.

In: Genes and Development, Vol. 12, No. 12, 15.06.1998, p. 1825-1836.

Research output: Contribution to journalArticle

Britsch, S, Li, L, Kirchhoff, S, Theuring, F, Brinkmann, V, Birchmeier, C & Riethmacher, D 1998, 'The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system', Genes and Development, vol. 12, no. 12, pp. 1825-1836.
Britsch S, Li L, Kirchhoff S, Theuring F, Brinkmann V, Birchmeier C et al. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes and Development. 1998 Jun 15;12(12):1825-1836.
Britsch, Stefan ; Li, Li ; Kirchhoff, Susanne ; Theuring, Franz ; Brinkmann, Volker ; Birchmeier, Carmen ; Riethmacher, Dieter. / The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. In: Genes and Development. 1998 ; Vol. 12, No. 12. pp. 1825-1836.
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