The extracellular domain of CD4 receptor possesses a protein kinase activity

Leonid A. Yakubov, Yury Y. Kit, Vladimir A. Richter, Anna Y. Andreeva, Valery N. Karamyshev, C. A. Stein, Valentin V. Vlassov

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The CD4 receptor of T-helper cells is an essential participant in immune response formation and HIV infection. We report here that the extracellular domains of CD4 receptor can catalyse the phosphotransferase (kinase) reaction. Incubation of rsCD4 in solution with [γ-32P]ATP results in the Ca2+-dependent autophosphorylation of the protein presumably at a His residue because the reaction is prevented by the diethylpyrocarbonate treatment. The rsCD4 phosphorylates milk casein or human plasma proteins as a Ser/Thr protein kinase.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalFEBS Letters
Issue number1
Publication statusPublished - Jul 10 1998
Externally publishedYes


  • Autophosphorylation
  • CD4 receptor
  • Protein kinase
  • T-lymphocyte

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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