The genome sequence of Yersinia pestis bacteriophage φA1122 reveals an intimate history with the coliphage T3 and T7 genomes

Emilio Garcia, Jeffrey M. Elliott, Erlan Ramanculov, Patrick S G Chain, May C. Chu, Ian J. Molineux

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The genome sequence of bacteriophage φA1122 has been determined. φA1122 grows on almost all isolates of Yersinia pestis and is used by the Centers for Disease Control and Prevention as a diagnostic agent for the causative agent of plague. φA1122 is very closely related to coliphage T7; the two genomes are colinear, and the genome-wide level of nucleotide identity is about 89%. However, a quarter of the φA1122 genome, one that includes about half of the morphogenetic and maturation functions, is significantly more closely related to coliphage T3 than to T7. It is proposed that the yersiniophage φA1122 recombined with a close relative of the Y. enterocolitica phage φYeO3-12 to yield progeny phages, one of which became the classic T3 coliphage of Demerec and Fano (M. Demerec and U. Fano, Genetics 30:119-136, 1945).

Original languageEnglish
Pages (from-to)5248-5262
Number of pages15
JournalJournal of Bacteriology
Volume185
Issue number17
DOIs
Publication statusPublished - Sep 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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