The in vivo delivery of heterologous proteins by microencapsulated recombinant cells

Patricia L. Chang, Jeremy M. Van Raamsdonk, Gonzalo Hortelano, Susan C. Barsoum, Nicole C. MacDonald, Tracy L. Stockley

Research output: Contribution to journalReview article

66 Citations (Scopus)

Abstract

The microencapsulation of recombinant cells is a novel and potentially cost-effective method of heterologous protein delivery. A 'universal' cell line, genetically modified to secrete any desired protein, is immunologically protected from tissue rejection by enclosure in microcapsules. The microcapsule can then be implanted in different recipients to deliver recombinant proteins in vivo.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalTrends in Biotechnology
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1 1999

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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    Chang, P. L., Van Raamsdonk, J. M., Hortelano, G., Barsoum, S. C., MacDonald, N. C., & Stockley, T. L. (1999). The in vivo delivery of heterologous proteins by microencapsulated recombinant cells. Trends in Biotechnology, 17(2), 78-83. https://doi.org/10.1016/S0167-7799(98)01250-5