The in vivo delivery of heterologous proteins by microencapsulated recombinant cells

Patricia L. Chang, Jeremy M. Van Raamsdonk, Gonzalo Hortelano, Susan C. Barsoum, Nicole C. MacDonald, Tracy L. Stockley

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The microencapsulation of recombinant cells is a novel and potentially cost-effective method of heterologous protein delivery. A 'universal' cell line, genetically modified to secrete any desired protein, is immunologically protected from tissue rejection by enclosure in microcapsules. The microcapsule can then be implanted in different recipients to deliver recombinant proteins in vivo.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalTrends in Biotechnology
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1 1999
Externally publishedYes

Fingerprint

Recombinant Proteins
Capsules
Proteins
Microencapsulation
Recombinant proteins
Drug Compounding
Enclosures
Cells
Tissue
Costs and Cost Analysis
Cell Line
Costs

ASJC Scopus subject areas

  • Bioengineering

Cite this

Chang, P. L., Van Raamsdonk, J. M., Hortelano, G., Barsoum, S. C., MacDonald, N. C., & Stockley, T. L. (1999). The in vivo delivery of heterologous proteins by microencapsulated recombinant cells. Trends in Biotechnology, 17(2), 78-83. https://doi.org/10.1016/S0167-7799(98)01250-5

The in vivo delivery of heterologous proteins by microencapsulated recombinant cells. / Chang, Patricia L.; Van Raamsdonk, Jeremy M.; Hortelano, Gonzalo; Barsoum, Susan C.; MacDonald, Nicole C.; Stockley, Tracy L.

In: Trends in Biotechnology, Vol. 17, No. 2, 01.02.1999, p. 78-83.

Research output: Contribution to journalArticle

Chang, PL, Van Raamsdonk, JM, Hortelano, G, Barsoum, SC, MacDonald, NC & Stockley, TL 1999, 'The in vivo delivery of heterologous proteins by microencapsulated recombinant cells', Trends in Biotechnology, vol. 17, no. 2, pp. 78-83. https://doi.org/10.1016/S0167-7799(98)01250-5
Chang, Patricia L. ; Van Raamsdonk, Jeremy M. ; Hortelano, Gonzalo ; Barsoum, Susan C. ; MacDonald, Nicole C. ; Stockley, Tracy L. / The in vivo delivery of heterologous proteins by microencapsulated recombinant cells. In: Trends in Biotechnology. 1999 ; Vol. 17, No. 2. pp. 78-83.
@article{b8a4d7dfae72421b9174a8dbb20fe264,
title = "The in vivo delivery of heterologous proteins by microencapsulated recombinant cells",
abstract = "The microencapsulation of recombinant cells is a novel and potentially cost-effective method of heterologous protein delivery. A 'universal' cell line, genetically modified to secrete any desired protein, is immunologically protected from tissue rejection by enclosure in microcapsules. The microcapsule can then be implanted in different recipients to deliver recombinant proteins in vivo.",
author = "Chang, {Patricia L.} and {Van Raamsdonk}, {Jeremy M.} and Gonzalo Hortelano and Barsoum, {Susan C.} and MacDonald, {Nicole C.} and Stockley, {Tracy L.}",
year = "1999",
month = "2",
day = "1",
doi = "10.1016/S0167-7799(98)01250-5",
language = "English",
volume = "17",
pages = "78--83",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - The in vivo delivery of heterologous proteins by microencapsulated recombinant cells

AU - Chang, Patricia L.

AU - Van Raamsdonk, Jeremy M.

AU - Hortelano, Gonzalo

AU - Barsoum, Susan C.

AU - MacDonald, Nicole C.

AU - Stockley, Tracy L.

PY - 1999/2/1

Y1 - 1999/2/1

N2 - The microencapsulation of recombinant cells is a novel and potentially cost-effective method of heterologous protein delivery. A 'universal' cell line, genetically modified to secrete any desired protein, is immunologically protected from tissue rejection by enclosure in microcapsules. The microcapsule can then be implanted in different recipients to deliver recombinant proteins in vivo.

AB - The microencapsulation of recombinant cells is a novel and potentially cost-effective method of heterologous protein delivery. A 'universal' cell line, genetically modified to secrete any desired protein, is immunologically protected from tissue rejection by enclosure in microcapsules. The microcapsule can then be implanted in different recipients to deliver recombinant proteins in vivo.

UR - http://www.scopus.com/inward/record.url?scp=0033079678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033079678&partnerID=8YFLogxK

U2 - 10.1016/S0167-7799(98)01250-5

DO - 10.1016/S0167-7799(98)01250-5

M3 - Article

VL - 17

SP - 78

EP - 83

JO - Trends in Biotechnology

JF - Trends in Biotechnology

SN - 0167-7799

IS - 2

ER -