The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor

Noona Ambartsumian; Jörg Klingelhöfer; Mariam Grigorian; Claus Christensen; Marina Kriajevska; Eugene Tulchinsky; Georgii Georgiev; Vladimir Berezin; Elisabeth Bock; Jørgen Rygaard; Renhai Cao; Yihai Cao; Eugene Lukanidin

doi:10.1038/sj.onc.1204636

The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor

Noona Ambartsumian, Jörg Klingelhöfer, Mariam Grigorian, Claus Christensen, Marina Kriajevska, Eugene Tulchinsky, Georgii Georgiev, Vladimir Berezin, Elisabeth Bock, Jørgen Rygaard, Renhai Cao, Yihai Cao, Eugene Lukanidin

Research output: Contribution to journal › Article › peer-review

221 Citations (Scopus)

Abstract

The involvement of Mts1(S100A4), a small Ca²⁺-binding protein in tumor progression and metastasis had been demonstrated. However, the mechanism by which mts1(S100A4) promoted metastasis had not been identified. Here we demonstrated that Mts1(S100A4) had significant stimulatory effect on the angiogenesis. We detected high incidence of hemangiomas - benign tumors of vascular origin in aged transgenic mice ubiquitously expressing the mts1(S100A4) gene. Furthermore, the serum level of the Mts1(S100A4) protein increased with ageing. Tumors developed in Mts1-transgenic mice revealed an enhanced vascular density. We showed that an oligomeric, but not a dimeric form of the Mts1(S100A4) protein was capable of enhancing the endothelial cell motility in vitro and stimulate the corneal neovascularization in vivo. An oligomeric fraction of the protein was detected in the conditioned media as well as in human serum. The data obtained allowed us to conclude that mts1(S100A4) might induce tumor progression via stimulation of angiogenesis.

Original language	English
Pages (from-to)	4685-4695
Number of pages	11
Journal	Oncogene
Volume	20
Issue number	34
DOIs	https://doi.org/10.1038/sj.onc.1204636
Publication status	Published - Aug 2 2001
Externally published	Yes

Keywords

Angiogenesis
S100A4
Stimulation of motility

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/sj.onc.1204636

Cite this

@article{7996d43a7f0c406cb4e7df28f7d1055a,

title = "The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor",

abstract = "The involvement of Mts1(S100A4), a small Ca2+-binding protein in tumor progression and metastasis had been demonstrated. However, the mechanism by which mts1(S100A4) promoted metastasis had not been identified. Here we demonstrated that Mts1(S100A4) had significant stimulatory effect on the angiogenesis. We detected high incidence of hemangiomas - benign tumors of vascular origin in aged transgenic mice ubiquitously expressing the mts1(S100A4) gene. Furthermore, the serum level of the Mts1(S100A4) protein increased with ageing. Tumors developed in Mts1-transgenic mice revealed an enhanced vascular density. We showed that an oligomeric, but not a dimeric form of the Mts1(S100A4) protein was capable of enhancing the endothelial cell motility in vitro and stimulate the corneal neovascularization in vivo. An oligomeric fraction of the protein was detected in the conditioned media as well as in human serum. The data obtained allowed us to conclude that mts1(S100A4) might induce tumor progression via stimulation of angiogenesis.",

keywords = "Angiogenesis, S100A4, Stimulation of motility",

author = "Noona Ambartsumian and J{\"o}rg Klingelh{\"o}fer and Mariam Grigorian and Claus Christensen and Marina Kriajevska and Eugene Tulchinsky and Georgii Georgiev and Vladimir Berezin and Elisabeth Bock and J{\o}rgen Rygaard and Renhai Cao and Yihai Cao and Eugene Lukanidin",

year = "2001",

month = aug,

day = "2",

doi = "10.1038/sj.onc.1204636",

language = "English",

volume = "20",

pages = "4685--4695",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Nature Publishing Group",

number = "34",

}

TY - JOUR

T1 - The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor

AU - Ambartsumian, Noona

AU - Klingelhöfer, Jörg

AU - Grigorian, Mariam

AU - Christensen, Claus

AU - Kriajevska, Marina

AU - Tulchinsky, Eugene

AU - Georgiev, Georgii

AU - Berezin, Vladimir

AU - Bock, Elisabeth

AU - Rygaard, Jørgen

AU - Cao, Renhai

AU - Cao, Yihai

AU - Lukanidin, Eugene

PY - 2001/8/2

Y1 - 2001/8/2

N2 - The involvement of Mts1(S100A4), a small Ca2+-binding protein in tumor progression and metastasis had been demonstrated. However, the mechanism by which mts1(S100A4) promoted metastasis had not been identified. Here we demonstrated that Mts1(S100A4) had significant stimulatory effect on the angiogenesis. We detected high incidence of hemangiomas - benign tumors of vascular origin in aged transgenic mice ubiquitously expressing the mts1(S100A4) gene. Furthermore, the serum level of the Mts1(S100A4) protein increased with ageing. Tumors developed in Mts1-transgenic mice revealed an enhanced vascular density. We showed that an oligomeric, but not a dimeric form of the Mts1(S100A4) protein was capable of enhancing the endothelial cell motility in vitro and stimulate the corneal neovascularization in vivo. An oligomeric fraction of the protein was detected in the conditioned media as well as in human serum. The data obtained allowed us to conclude that mts1(S100A4) might induce tumor progression via stimulation of angiogenesis.

AB - The involvement of Mts1(S100A4), a small Ca2+-binding protein in tumor progression and metastasis had been demonstrated. However, the mechanism by which mts1(S100A4) promoted metastasis had not been identified. Here we demonstrated that Mts1(S100A4) had significant stimulatory effect on the angiogenesis. We detected high incidence of hemangiomas - benign tumors of vascular origin in aged transgenic mice ubiquitously expressing the mts1(S100A4) gene. Furthermore, the serum level of the Mts1(S100A4) protein increased with ageing. Tumors developed in Mts1-transgenic mice revealed an enhanced vascular density. We showed that an oligomeric, but not a dimeric form of the Mts1(S100A4) protein was capable of enhancing the endothelial cell motility in vitro and stimulate the corneal neovascularization in vivo. An oligomeric fraction of the protein was detected in the conditioned media as well as in human serum. The data obtained allowed us to conclude that mts1(S100A4) might induce tumor progression via stimulation of angiogenesis.

KW - Angiogenesis

KW - S100A4

KW - Stimulation of motility

UR - http://www.scopus.com/inward/record.url?scp=17944368283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17944368283&partnerID=8YFLogxK

U2 - 10.1038/sj.onc.1204636

DO - 10.1038/sj.onc.1204636

M3 - Article

C2 - 11498791

AN - SCOPUS:17944368283

SN - 0950-9232

VL - 20

SP - 4685

EP - 4695

JO - Oncogene

JF - Oncogene

IS - 34

ER -

The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this