The mouse has a Polycomb-like chromobox gene

J J Pearce, P B Singh, S J Gaunt

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

The Drosophila gene Polycomb (Pc) has been implicated in the clonal inheritance of determined states and is a trans-regulator of the Antennapedia-like homeobox genes. Pc shares a region of homology (the chromobox) with the Drosophila gene Heterochromatin Protein 1 (HP1), a component of heterochromatin. The Pc chromobox has been used to isolate a mouse chromobox gene, M33, which encodes a predicted 519 amino acid protein. The M33 chromodomain is more similar to that in the Pc protein, than that in the HP1 protein. In addition to the chromodomain, the M33 and Pc proteins also share a region of homology at their C termini. The temporal and spatial expression patterns of M33 have been studied by in situ hybridization and northern analysis. During the final 10 days of embryonic development, M33 expression mirrors that of the cell-cycle-specific cyclin B gene. It is therefore suggested that the rate of cellular proliferation controls M33 expression. From comparisons of the characteristics of M33 with those of Pc it is proposed that M33 is a Pc-like chromobox gene. The roles of M33 and Pc in models of cellular memory are examined and implications of the memory models addressed.

Original languageEnglish
Pages (from-to)921-9
Number of pages9
JournalDevelopment
Volume114
Issue number4
Publication statusPublished - Apr 1992

Fingerprint

Genes
Proteins
Cyclin B
Heterochromatin
Homeobox Genes
Drosophila
Embryonic Development
In Situ Hybridization
Cell Cycle
Cell Proliferation
Amino Acids
heterochromatin-specific nonhistone chromosomal protein HP-1
Drosophila heterochromatin protein 1

Keywords

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Drosophila
  • Embryo, Mammalian
  • Embryo, Nonmammalian
  • Genes, Homeobox
  • Mice
  • Molecular Probe Techniques
  • Molecular Sequence Data
  • Sequence Homology, Nucleic Acid
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Pearce, J. J., Singh, P. B., & Gaunt, S. J. (1992). The mouse has a Polycomb-like chromobox gene. Development, 114(4), 921-9.

The mouse has a Polycomb-like chromobox gene. / Pearce, J J; Singh, P B; Gaunt, S J.

In: Development, Vol. 114, No. 4, 04.1992, p. 921-9.

Research output: Contribution to journalArticle

Pearce, JJ, Singh, PB & Gaunt, SJ 1992, 'The mouse has a Polycomb-like chromobox gene', Development, vol. 114, no. 4, pp. 921-9.
Pearce JJ, Singh PB, Gaunt SJ. The mouse has a Polycomb-like chromobox gene. Development. 1992 Apr;114(4):921-9.
Pearce, J J ; Singh, P B ; Gaunt, S J. / The mouse has a Polycomb-like chromobox gene. In: Development. 1992 ; Vol. 114, No. 4. pp. 921-9.
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AB - The Drosophila gene Polycomb (Pc) has been implicated in the clonal inheritance of determined states and is a trans-regulator of the Antennapedia-like homeobox genes. Pc shares a region of homology (the chromobox) with the Drosophila gene Heterochromatin Protein 1 (HP1), a component of heterochromatin. The Pc chromobox has been used to isolate a mouse chromobox gene, M33, which encodes a predicted 519 amino acid protein. The M33 chromodomain is more similar to that in the Pc protein, than that in the HP1 protein. In addition to the chromodomain, the M33 and Pc proteins also share a region of homology at their C termini. The temporal and spatial expression patterns of M33 have been studied by in situ hybridization and northern analysis. During the final 10 days of embryonic development, M33 expression mirrors that of the cell-cycle-specific cyclin B gene. It is therefore suggested that the rate of cellular proliferation controls M33 expression. From comparisons of the characteristics of M33 with those of Pc it is proposed that M33 is a Pc-like chromobox gene. The roles of M33 and Pc in models of cellular memory are examined and implications of the memory models addressed.

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