The relationship between oxidative stress, inflammation, and atherosclerosis in renal transplant and end-stage renal disease patients

Kultigin Turkmen, Halil Zeki Tonbul, Aysun Toker, Abduzhappar Gaipov, Fatih Mehmet Erdur, Humeyra Cicekler, Melih Anil, Orhan Ozbek, Nedim Yilmaz Selcuk, Mehdi Yeksan, Suleyman Turk

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objectives: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and is also found to be ongoing in renal transplant (Rtx) patients. As a sign of atherosclerosis, increased carotid intimamedia thickness (CIMT) has been widely accepted as a strong predictor of cardiovascular disease (CVD) and mortality in the end-stage renal disease (ESRD) patients. Ischemia-modified albumin (IMA), pentraxin-3 (PTX-3), and neutrophil-to- lymphocyte ratio (NLR) were introduced as oxidative stress and inflammatory biomarkers in ESRD. The role of Rtx in terms of atherogenesis, oxidative stress, and inflammation is still unclear. We aimed to investigate the relationship between IMA, PTX-3, NLR, and CIMT in Rtx patients without overt CVD and to compare these results with those obtained from healthy subjects and ESRD patients receiving hemodialysis (HD) and peritoneal dialysis (PD). Design and methods: Cross-sectional analysis in which CIMT measurements, NLR, and serum PTX-3 and IMA levels were assessed in 18 Rtx patients (10 females; mean age: 40.0 ± 13.3 years), 16 PD patients (7 females; 40.2 ± 12.9 years), 14 HD patients (8 females; 46.6 ± 10.7 years), and 19 healthy subjects (9 females; 36.9 ± 8.9 years). Results: IMA, PTX-3, and high-sensitive C-reactive protein (hs-CRP) levels, NLR, and CIMT of Rtx patients were found to be significantly higher compared with healthy subjects (p = 0.04, p < 0.0001, p < 0.005, p 0.005, and p 0.005, respectively). IMA level was positively correlated with hs-CRP and PTX-3 levels, NLR, and CIMT when all participants were included (r = 0.338, p 0.005; r = 0.485, p < 0.0001; r = 0.304, p = 0.013; and r = 0.499, p < 0.0001, respectively). Conclusion: There has been ongoing inflammation, oxidative stress, and atherosclerosis in Rtx patients.

Original languageEnglish
Pages (from-to)1229-1237
Number of pages9
JournalRenal Failure
Volume34
Issue number10
DOIs
Publication statusPublished - Nov 1 2012
Externally publishedYes

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Chronic Kidney Failure
Atherosclerosis
Oxidative Stress
Inflammation
Transplants
Kidney
Neutrophils
Lymphocytes
Healthy Volunteers
Peritoneal Dialysis
C-Reactive Protein
Renal Dialysis
Cardiovascular Diseases
Carotid Artery Diseases
Chronic Renal Insufficiency
Cross-Sectional Studies
Biomarkers
PTX3 protein
ischemia-modified albumin
Mortality

Keywords

  • Carotid intimamedia thickness
  • End-stage renal disease
  • Ischemia-modified albumin
  • Neutrophil-to-lymphocyte ratio
  • Pentraxin-3
  • Renal transplantation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nephrology

Cite this

The relationship between oxidative stress, inflammation, and atherosclerosis in renal transplant and end-stage renal disease patients. / Turkmen, Kultigin; Tonbul, Halil Zeki; Toker, Aysun; Gaipov, Abduzhappar; Erdur, Fatih Mehmet; Cicekler, Humeyra; Anil, Melih; Ozbek, Orhan; Selcuk, Nedim Yilmaz; Yeksan, Mehdi; Turk, Suleyman.

In: Renal Failure, Vol. 34, No. 10, 01.11.2012, p. 1229-1237.

Research output: Contribution to journalArticle

Turkmen, K, Tonbul, HZ, Toker, A, Gaipov, A, Erdur, FM, Cicekler, H, Anil, M, Ozbek, O, Selcuk, NY, Yeksan, M & Turk, S 2012, 'The relationship between oxidative stress, inflammation, and atherosclerosis in renal transplant and end-stage renal disease patients', Renal Failure, vol. 34, no. 10, pp. 1229-1237. https://doi.org/10.3109/0886022X.2012.723580
Turkmen, Kultigin ; Tonbul, Halil Zeki ; Toker, Aysun ; Gaipov, Abduzhappar ; Erdur, Fatih Mehmet ; Cicekler, Humeyra ; Anil, Melih ; Ozbek, Orhan ; Selcuk, Nedim Yilmaz ; Yeksan, Mehdi ; Turk, Suleyman. / The relationship between oxidative stress, inflammation, and atherosclerosis in renal transplant and end-stage renal disease patients. In: Renal Failure. 2012 ; Vol. 34, No. 10. pp. 1229-1237.
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AU - Tonbul, Halil Zeki

AU - Toker, Aysun

AU - Gaipov, Abduzhappar

AU - Erdur, Fatih Mehmet

AU - Cicekler, Humeyra

AU - Anil, Melih

AU - Ozbek, Orhan

AU - Selcuk, Nedim Yilmaz

AU - Yeksan, Mehdi

AU - Turk, Suleyman

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N2 - Objectives: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and is also found to be ongoing in renal transplant (Rtx) patients. As a sign of atherosclerosis, increased carotid intimamedia thickness (CIMT) has been widely accepted as a strong predictor of cardiovascular disease (CVD) and mortality in the end-stage renal disease (ESRD) patients. Ischemia-modified albumin (IMA), pentraxin-3 (PTX-3), and neutrophil-to- lymphocyte ratio (NLR) were introduced as oxidative stress and inflammatory biomarkers in ESRD. The role of Rtx in terms of atherogenesis, oxidative stress, and inflammation is still unclear. We aimed to investigate the relationship between IMA, PTX-3, NLR, and CIMT in Rtx patients without overt CVD and to compare these results with those obtained from healthy subjects and ESRD patients receiving hemodialysis (HD) and peritoneal dialysis (PD). Design and methods: Cross-sectional analysis in which CIMT measurements, NLR, and serum PTX-3 and IMA levels were assessed in 18 Rtx patients (10 females; mean age: 40.0 ± 13.3 years), 16 PD patients (7 females; 40.2 ± 12.9 years), 14 HD patients (8 females; 46.6 ± 10.7 years), and 19 healthy subjects (9 females; 36.9 ± 8.9 years). Results: IMA, PTX-3, and high-sensitive C-reactive protein (hs-CRP) levels, NLR, and CIMT of Rtx patients were found to be significantly higher compared with healthy subjects (p = 0.04, p < 0.0001, p < 0.005, p 0.005, and p 0.005, respectively). IMA level was positively correlated with hs-CRP and PTX-3 levels, NLR, and CIMT when all participants were included (r = 0.338, p 0.005; r = 0.485, p < 0.0001; r = 0.304, p = 0.013; and r = 0.499, p < 0.0001, respectively). Conclusion: There has been ongoing inflammation, oxidative stress, and atherosclerosis in Rtx patients.

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KW - Neutrophil-to-lymphocyte ratio

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KW - Renal transplantation

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