The relationship between oxidative stress, inflammation, and atherosclerosis in renal transplant and end-stage renal disease patients

Kultigin Turkmen, Halil Zeki Tonbul, Aysun Toker, Abduzhappar Gaipov, Fatih Mehmet Erdur, Humeyra Cicekler, Melih Anil, Orhan Ozbek, Nedim Yilmaz Selcuk, Mehdi Yeksan, Suleyman Turk

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objectives: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and is also found to be ongoing in renal transplant (Rtx) patients. As a sign of atherosclerosis, increased carotid intimamedia thickness (CIMT) has been widely accepted as a strong predictor of cardiovascular disease (CVD) and mortality in the end-stage renal disease (ESRD) patients. Ischemia-modified albumin (IMA), pentraxin-3 (PTX-3), and neutrophil-to- lymphocyte ratio (NLR) were introduced as oxidative stress and inflammatory biomarkers in ESRD. The role of Rtx in terms of atherogenesis, oxidative stress, and inflammation is still unclear. We aimed to investigate the relationship between IMA, PTX-3, NLR, and CIMT in Rtx patients without overt CVD and to compare these results with those obtained from healthy subjects and ESRD patients receiving hemodialysis (HD) and peritoneal dialysis (PD). Design and methods: Cross-sectional analysis in which CIMT measurements, NLR, and serum PTX-3 and IMA levels were assessed in 18 Rtx patients (10 females; mean age: 40.0 ± 13.3 years), 16 PD patients (7 females; 40.2 ± 12.9 years), 14 HD patients (8 females; 46.6 ± 10.7 years), and 19 healthy subjects (9 females; 36.9 ± 8.9 years). Results: IMA, PTX-3, and high-sensitive C-reactive protein (hs-CRP) levels, NLR, and CIMT of Rtx patients were found to be significantly higher compared with healthy subjects (p = 0.04, p < 0.0001, p < 0.005, p 0.005, and p 0.005, respectively). IMA level was positively correlated with hs-CRP and PTX-3 levels, NLR, and CIMT when all participants were included (r = 0.338, p 0.005; r = 0.485, p < 0.0001; r = 0.304, p = 0.013; and r = 0.499, p < 0.0001, respectively). Conclusion: There has been ongoing inflammation, oxidative stress, and atherosclerosis in Rtx patients.

Original languageEnglish
Pages (from-to)1229-1237
Number of pages9
JournalRenal Failure
Volume34
Issue number10
DOIs
Publication statusPublished - Nov 1 2012
Externally publishedYes

Keywords

  • Carotid intimamedia thickness
  • End-stage renal disease
  • Ischemia-modified albumin
  • Neutrophil-to-lymphocyte ratio
  • Pentraxin-3
  • Renal transplantation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nephrology

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  • Cite this

    Turkmen, K., Tonbul, H. Z., Toker, A., Gaipov, A., Erdur, F. M., Cicekler, H., Anil, M., Ozbek, O., Selcuk, N. Y., Yeksan, M., & Turk, S. (2012). The relationship between oxidative stress, inflammation, and atherosclerosis in renal transplant and end-stage renal disease patients. Renal Failure, 34(10), 1229-1237. https://doi.org/10.3109/0886022X.2012.723580