Abstract
Objectives: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and is also found to be ongoing in renal transplant (Rtx) patients. As a sign of atherosclerosis, increased carotid intimamedia thickness (CIMT) has been widely accepted as a strong predictor of cardiovascular disease (CVD) and mortality in the end-stage renal disease (ESRD) patients. Ischemia-modified albumin (IMA), pentraxin-3 (PTX-3), and neutrophil-to- lymphocyte ratio (NLR) were introduced as oxidative stress and inflammatory biomarkers in ESRD. The role of Rtx in terms of atherogenesis, oxidative stress, and inflammation is still unclear. We aimed to investigate the relationship between IMA, PTX-3, NLR, and CIMT in Rtx patients without overt CVD and to compare these results with those obtained from healthy subjects and ESRD patients receiving hemodialysis (HD) and peritoneal dialysis (PD). Design and methods: Cross-sectional analysis in which CIMT measurements, NLR, and serum PTX-3 and IMA levels were assessed in 18 Rtx patients (10 females; mean age: 40.0 ± 13.3 years), 16 PD patients (7 females; 40.2 ± 12.9 years), 14 HD patients (8 females; 46.6 ± 10.7 years), and 19 healthy subjects (9 females; 36.9 ± 8.9 years). Results: IMA, PTX-3, and high-sensitive C-reactive protein (hs-CRP) levels, NLR, and CIMT of Rtx patients were found to be significantly higher compared with healthy subjects (p = 0.04, p < 0.0001, p < 0.005, p 0.005, and p 0.005, respectively). IMA level was positively correlated with hs-CRP and PTX-3 levels, NLR, and CIMT when all participants were included (r = 0.338, p 0.005; r = 0.485, p < 0.0001; r = 0.304, p = 0.013; and r = 0.499, p < 0.0001, respectively). Conclusion: There has been ongoing inflammation, oxidative stress, and atherosclerosis in Rtx patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1229-1237 |
| Number of pages | 9 |
| Journal | Renal Failure |
| Volume | 34 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Nov 1 2012 |
| Externally published | Yes |
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Keywords
- Carotid intimamedia thickness
- End-stage renal disease
- Ischemia-modified albumin
- Neutrophil-to-lymphocyte ratio
- Pentraxin-3
- Renal transplantation
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Nephrology
Cite this
The relationship between oxidative stress, inflammation, and atherosclerosis in renal transplant and end-stage renal disease patients. / Turkmen, Kultigin; Tonbul, Halil Zeki; Toker, Aysun; Gaipov, Abduzhappar; Erdur, Fatih Mehmet; Cicekler, Humeyra; Anil, Melih; Ozbek, Orhan; Selcuk, Nedim Yilmaz; Yeksan, Mehdi; Turk, Suleyman.
In: Renal Failure, Vol. 34, No. 10, 01.11.2012, p. 1229-1237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The relationship between oxidative stress, inflammation, and atherosclerosis in renal transplant and end-stage renal disease patients
AU - Turkmen, Kultigin
AU - Tonbul, Halil Zeki
AU - Toker, Aysun
AU - Gaipov, Abduzhappar
AU - Erdur, Fatih Mehmet
AU - Cicekler, Humeyra
AU - Anil, Melih
AU - Ozbek, Orhan
AU - Selcuk, Nedim Yilmaz
AU - Yeksan, Mehdi
AU - Turk, Suleyman
PY - 2012/11/1
Y1 - 2012/11/1
N2 - Objectives: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and is also found to be ongoing in renal transplant (Rtx) patients. As a sign of atherosclerosis, increased carotid intimamedia thickness (CIMT) has been widely accepted as a strong predictor of cardiovascular disease (CVD) and mortality in the end-stage renal disease (ESRD) patients. Ischemia-modified albumin (IMA), pentraxin-3 (PTX-3), and neutrophil-to- lymphocyte ratio (NLR) were introduced as oxidative stress and inflammatory biomarkers in ESRD. The role of Rtx in terms of atherogenesis, oxidative stress, and inflammation is still unclear. We aimed to investigate the relationship between IMA, PTX-3, NLR, and CIMT in Rtx patients without overt CVD and to compare these results with those obtained from healthy subjects and ESRD patients receiving hemodialysis (HD) and peritoneal dialysis (PD). Design and methods: Cross-sectional analysis in which CIMT measurements, NLR, and serum PTX-3 and IMA levels were assessed in 18 Rtx patients (10 females; mean age: 40.0 ± 13.3 years), 16 PD patients (7 females; 40.2 ± 12.9 years), 14 HD patients (8 females; 46.6 ± 10.7 years), and 19 healthy subjects (9 females; 36.9 ± 8.9 years). Results: IMA, PTX-3, and high-sensitive C-reactive protein (hs-CRP) levels, NLR, and CIMT of Rtx patients were found to be significantly higher compared with healthy subjects (p = 0.04, p < 0.0001, p < 0.005, p 0.005, and p 0.005, respectively). IMA level was positively correlated with hs-CRP and PTX-3 levels, NLR, and CIMT when all participants were included (r = 0.338, p 0.005; r = 0.485, p < 0.0001; r = 0.304, p = 0.013; and r = 0.499, p < 0.0001, respectively). Conclusion: There has been ongoing inflammation, oxidative stress, and atherosclerosis in Rtx patients.
AB - Objectives: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and is also found to be ongoing in renal transplant (Rtx) patients. As a sign of atherosclerosis, increased carotid intimamedia thickness (CIMT) has been widely accepted as a strong predictor of cardiovascular disease (CVD) and mortality in the end-stage renal disease (ESRD) patients. Ischemia-modified albumin (IMA), pentraxin-3 (PTX-3), and neutrophil-to- lymphocyte ratio (NLR) were introduced as oxidative stress and inflammatory biomarkers in ESRD. The role of Rtx in terms of atherogenesis, oxidative stress, and inflammation is still unclear. We aimed to investigate the relationship between IMA, PTX-3, NLR, and CIMT in Rtx patients without overt CVD and to compare these results with those obtained from healthy subjects and ESRD patients receiving hemodialysis (HD) and peritoneal dialysis (PD). Design and methods: Cross-sectional analysis in which CIMT measurements, NLR, and serum PTX-3 and IMA levels were assessed in 18 Rtx patients (10 females; mean age: 40.0 ± 13.3 years), 16 PD patients (7 females; 40.2 ± 12.9 years), 14 HD patients (8 females; 46.6 ± 10.7 years), and 19 healthy subjects (9 females; 36.9 ± 8.9 years). Results: IMA, PTX-3, and high-sensitive C-reactive protein (hs-CRP) levels, NLR, and CIMT of Rtx patients were found to be significantly higher compared with healthy subjects (p = 0.04, p < 0.0001, p < 0.005, p 0.005, and p 0.005, respectively). IMA level was positively correlated with hs-CRP and PTX-3 levels, NLR, and CIMT when all participants were included (r = 0.338, p 0.005; r = 0.485, p < 0.0001; r = 0.304, p = 0.013; and r = 0.499, p < 0.0001, respectively). Conclusion: There has been ongoing inflammation, oxidative stress, and atherosclerosis in Rtx patients.
KW - Carotid intimamedia thickness
KW - End-stage renal disease
KW - Ischemia-modified albumin
KW - Neutrophil-to-lymphocyte ratio
KW - Pentraxin-3
KW - Renal transplantation
UR - http://www.scopus.com/inward/record.url?scp=84867705339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867705339&partnerID=8YFLogxK
U2 - 10.3109/0886022X.2012.723580
DO - 10.3109/0886022X.2012.723580
M3 - Article
VL - 34
SP - 1229
EP - 1237
JO - Renal Failure
JF - Renal Failure
SN - 0886-022X
IS - 10
ER -