The role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair.

Arman Saparov, Chien Wen Chen, Sarah A. Beckman, Yadong Wang, Johnny Huard

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Oxidative stress and inflammation play major roles in the pathogenesis of coronary heart disease including myocardial infarction (MI). The pathological progression following MI is very complex and involves a number of cell populations including cells localized within the heart, as well as cells recruited from the circulation and other tissues that participate in inflammatory and reparative processes. These cells, with their secretory factors, have pleiotropic effects that depend on the stage of inflammation and regeneration. Excessive inflammation leads to enlargement of the infarction site, pathological remodeling and eventually, heart dysfunction. Stem cell therapy represents a unique and innovative approach to ameliorate oxidative stress and inflammation caused by ischemic heart disease. Consequently, it is crucial to understand the crosstalk between stem cells and other cells involved in post-MI cardiac tissue repair, especially immune cells, in order to harness the beneficial effects of the immune response following MI and further improve stem cell-mediated cardiac regeneration. This paper reviews the recent findings on the role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair following ischemic heart disease, particularly acute MI and focuses specifically on mesenchymal, muscle and blood-vessel-derived stem cells due to their antioxidant and immunomodulatory properties.

Original languageEnglish
Pages (from-to)16258-16279
Number of pages22
JournalInternational Journal of Molecular Sciences
Volume14
Issue number8
Publication statusPublished - 2013

Fingerprint

myocardial infarction
Multipotent Stem Cells
Immunomodulation
stem cells
Stem cells
heart diseases
Repair
Myocardial Infarction
Stem Cells
Inflammation
cells
Oxidative stress
regeneration
Myocardial Ischemia
Regeneration
Oxidative Stress
infarction
Tissue
harnesses
pathogenesis

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Medicine(all)

Cite this

The role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair. / Saparov, Arman; Chen, Chien Wen; Beckman, Sarah A.; Wang, Yadong; Huard, Johnny.

In: International Journal of Molecular Sciences, Vol. 14, No. 8, 2013, p. 16258-16279.

Research output: Contribution to journalArticle

Saparov, Arman ; Chen, Chien Wen ; Beckman, Sarah A. ; Wang, Yadong ; Huard, Johnny. / The role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair. In: International Journal of Molecular Sciences. 2013 ; Vol. 14, No. 8. pp. 16258-16279.
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