Abstract
Mitochondria are dynamic organelles whose homeostasis is defined by two opposite processes: fission (or fragmentation), or fusion. Fission of mitochondria results in generation of smaller organelles and fusion is when they produce tubular or net-like structures. Although a number of proteins are already known to control the process of fission/fusion additional regulators controlling these processes are being found. The Bcl-2 family members take part in the regulation of apoptosis and according to the current view are involved in the mitochondrial net-like structure maintenance. In this review we will discuss mechanisms of mitochondrial fission/fusion regulation and summarize the available information on the role of Bcl-2 family members in the regulation of mitochondrial fission/fusion dynamics.
| Original language | English |
|---|---|
| Pages (from-to) | 184-191 |
| Number of pages | 8 |
| Journal | Tsitologiya |
| Volume | 57 |
| Issue number | 3 |
| Publication status | Published - 2015 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology