The spread of HIV in Pakistan

Bridging of the epidemic between populations

Muhammad R. Khanani, Mehreen Somani, Sadiq S. Rehmani, Nazle M C Veras, Marco Salemi, Syed H. Ali

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In the last two decades, 'concentrated epidemics' of human immunodeficiency virus (HIV) have established in several high risk groups in Pakistan, including Injecting Drug Users (IDUs) and among men who have sex with men (MSM). To explore the transmission patterns of HIV infection in these major high-risk groups of Pakistan, 76 HIV samples were analyzed from MSM, their female spouses and children, along with 26 samples from a previously studied cohort of IDUs. Phylogenetic analysis of HIV gag gene sequences obtained from these samples indicated a substantial degree of intermixing between the IDU and MSM populations, suggesting a bridging of HIV infection from IDUs, via MSM, to the MSM spouses and children. HIV epidemic in Pakistan is now spreading to the female spouses and offspring of bisexual MSM. HIV control and awareness programs must be refocused to include IDUs, MSM, as well as bisexual MSM, and their spouses and children.

Original languageEnglish
Article numbere22449
JournalPLoS One
Volume6
Issue number7
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Pakistan
Human immunodeficiency virus
spouses
Viruses
Drug Users
HIV
drugs
Spouses
risk groups
Population
HIV infections
Pharmaceutical Preparations
Virus Diseases
gag Genes
sampling
nucleotide sequences
gender
phylogeny
Genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Khanani, M. R., Somani, M., Rehmani, S. S., Veras, N. M. C., Salemi, M., & Ali, S. H. (2011). The spread of HIV in Pakistan: Bridging of the epidemic between populations. PLoS One, 6(7), [e22449]. https://doi.org/10.1371/journal.pone.0022449

The spread of HIV in Pakistan : Bridging of the epidemic between populations. / Khanani, Muhammad R.; Somani, Mehreen; Rehmani, Sadiq S.; Veras, Nazle M C; Salemi, Marco; Ali, Syed H.

In: PLoS One, Vol. 6, No. 7, e22449, 2011.

Research output: Contribution to journalArticle

Khanani, MR, Somani, M, Rehmani, SS, Veras, NMC, Salemi, M & Ali, SH 2011, 'The spread of HIV in Pakistan: Bridging of the epidemic between populations', PLoS One, vol. 6, no. 7, e22449. https://doi.org/10.1371/journal.pone.0022449
Khanani, Muhammad R. ; Somani, Mehreen ; Rehmani, Sadiq S. ; Veras, Nazle M C ; Salemi, Marco ; Ali, Syed H. / The spread of HIV in Pakistan : Bridging of the epidemic between populations. In: PLoS One. 2011 ; Vol. 6, No. 7.
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